Nature Communications (Apr 2021)
Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
- Giulia Della Chiara,
- Federica Gervasoni,
- Michaela Fakiola,
- Chiara Godano,
- Claudia D’Oria,
- Luca Azzolin,
- Raoul Jean Pierre Bonnal,
- Giulia Moreni,
- Lorenzo Drufuca,
- Grazisa Rossetti,
- Valeria Ranzani,
- Ramona Bason,
- Marco De Simone,
- Francesco Panariello,
- Ivan Ferrari,
- Tanya Fabbris,
- Francesca Zanconato,
- Mattia Forcato,
- Oriana Romano,
- Jimmy Caroli,
- Paola Gruarin,
- Maria Lucia Sarnicola,
- Michelangelo Cordenonsi,
- Alberto Bardelli,
- Nicola Zucchini,
- Andrea Pisani Ceretti,
- Nicolò Maria Mariani,
- Andrea Cassingena,
- Andrea Sartore-Bianchi,
- Giuseppe Testa,
- Luca Gianotti,
- Enrico Opocher,
- Federica Pisati,
- Claudio Tripodo,
- Giuseppe Macino,
- Salvatore Siena,
- Silvio Bicciato,
- Stefano Piccolo,
- Massimiliano Pagani
Affiliations
- Giulia Della Chiara
- IFOM, the FIRC Institute of Molecular Oncology
- Federica Gervasoni
- IFOM, the FIRC Institute of Molecular Oncology
- Michaela Fakiola
- IFOM, the FIRC Institute of Molecular Oncology
- Chiara Godano
- Istituto Nazionale Genetica Molecolare INGM ‘Romeo ed Enrica Invernizzi’
- Claudia D’Oria
- IFOM, the FIRC Institute of Molecular Oncology
- Luca Azzolin
- Department of Molecular Medicine, University of Padua
- Raoul Jean Pierre Bonnal
- IFOM, the FIRC Institute of Molecular Oncology
- Giulia Moreni
- Istituto Nazionale Genetica Molecolare INGM ‘Romeo ed Enrica Invernizzi’
- Lorenzo Drufuca
- IFOM, the FIRC Institute of Molecular Oncology
- Grazisa Rossetti
- IFOM, the FIRC Institute of Molecular Oncology
- Valeria Ranzani
- Istituto Nazionale Genetica Molecolare INGM ‘Romeo ed Enrica Invernizzi’
- Ramona Bason
- IFOM, the FIRC Institute of Molecular Oncology
- Marco De Simone
- Istituto Nazionale Genetica Molecolare INGM ‘Romeo ed Enrica Invernizzi’
- Francesco Panariello
- Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano
- Ivan Ferrari
- Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano
- Tanya Fabbris
- Istituto Nazionale Genetica Molecolare INGM ‘Romeo ed Enrica Invernizzi’
- Francesca Zanconato
- Department of Molecular Medicine, University of Padua
- Mattia Forcato
- Department of Life Sciences, University of Modena and Reggio Emilia
- Oriana Romano
- Department of Life Sciences, University of Modena and Reggio Emilia
- Jimmy Caroli
- Department of Life Sciences, University of Modena and Reggio Emilia
- Paola Gruarin
- Istituto Nazionale Genetica Molecolare INGM ‘Romeo ed Enrica Invernizzi’
- Maria Lucia Sarnicola
- Istituto Nazionale Genetica Molecolare INGM ‘Romeo ed Enrica Invernizzi’
- Michelangelo Cordenonsi
- Department of Molecular Medicine, University of Padua
- Alberto Bardelli
- Candiolo Cancer Institute, FPO - IRCCS
- Nicola Zucchini
- Department of Pathology, San Gerardo Hospital
- Andrea Pisani Ceretti
- UO Chirurgia Epatobiliopancreatica e Digestiva Ospedale San Paolo
- Nicolò Maria Mariani
- UO Chirurgia Epatobiliopancreatica e Digestiva Ospedale San Paolo
- Andrea Cassingena
- Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda
- Andrea Sartore-Bianchi
- Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda
- Giuseppe Testa
- Human Organoid Models Integrative Center HOMIC, University of Milan
- Luca Gianotti
- School of Medicine and Surgery, Milano-Bicocca University, and Department of Surgery, San Gerardo Hospital
- Enrico Opocher
- UO Chirurgia Epatobiliopancreatica e Digestiva Ospedale San Paolo
- Federica Pisati
- Histopathology Unit, Cogentech
- Claudio Tripodo
- Tumor Immunology Unit, University of Palermo
- Giuseppe Macino
- Department of Cellular Biotechnologies and Hematology, La Sapienza University of Rome
- Salvatore Siena
- Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda
- Silvio Bicciato
- Department of Life Sciences, University of Modena and Reggio Emilia
- Stefano Piccolo
- IFOM, the FIRC Institute of Molecular Oncology
- Massimiliano Pagani
- IFOM, the FIRC Institute of Molecular Oncology
- DOI
- https://doi.org/10.1038/s41467-021-22544-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
The role of epigenetic deregulation in colorectal cancer (CRC) is not fully understood yet. Here the authors use patient-derived organoids, epigenomics and single-cell RNA-seq to reveal that YAP/TAZ are key regulators that bind to active enhancers in CRC and promote tumour survival.
