What should you know about limbic encephalitis?

Abstract

Autoimmune encephalitis is an inflammatory disorder characterized by a subacute impairment of short-term memory, psychiatric features and seizures. It is often associated with a variety of other neurological symptoms, and its differential diagnosis is wide, leading to challenges in its recognition. It used to be regarded as a rare disease, usually paraneoplastic and with poor prognosis. However, with the recent recognition of membrane-surface directed antibodies, it is now known that in a substantial proportion of cases there is no association with any malignancy and there is a good prognosis if treated. Hence, early recognition and prompt initiation of immunotherapies are of great importance.

Keywords

• encefalite límbica autoimune
• encefalopatia
• antigénios intracelulares
• antigénios da superfície de membrana
• complexo VGKC
• LGI1
• CASPR
• N-metilaspartato
• síndrome paraneoplásica
• imunoterapia