Chicoric Acid: Natural Occurrence, Chemical Synthesis, Biosynthesis, and Their Bioactive Effects

Min Yang; Chao Wu; Chao Wu; Tianxi Zhang; Lei Shi; Jian Li; Jian Li; Hongbao Liang; Hongbao Liang; Xuzhen Lv; Fengtang Jing; Lu Qin; Tianlun Zhao; Chenxi Wang; Guangxu Liu; Shuai Feng; Feng Li

doi:10.3389/fchem.2022.888673

Frontiers in Chemistry (Jun 2022)

Chicoric Acid: Natural Occurrence, Chemical Synthesis, Biosynthesis, and Their Bioactive Effects

Min Yang,
Chao Wu,
Chao Wu,
Tianxi Zhang,
Lei Shi,
Jian Li,
Jian Li,
Hongbao Liang,
Hongbao Liang,
Xuzhen Lv,
Fengtang Jing,
Lu Qin,
Tianlun Zhao,
Chenxi Wang,
Guangxu Liu,
Shuai Feng,
Feng Li

Affiliations

Min Yang: Teaching and Research Office of Chinese Medicines authentication, College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China
Chao Wu: Teaching and Research Office of Chinese Medicines authentication, College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China
Chao Wu: Department of Pharmaceutical Preparation Technology, Department of Pharmaceutical Engineering, Shandong Drug and Food Vocational College, Weihai, China
Tianxi Zhang: Teaching and Research Office of Chinese Medicines authentication, College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China
Lei Shi: Teaching and Research Office of Chinese Medicines authentication, College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China
Jian Li: Teaching and Research Office of Chinese Medicines authentication, College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China
Jian Li: Grade Three Laboratory of Traditional Chinese Medicine Preparation, Department of Pharmacy, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China
Hongbao Liang: Teaching and Research Office of Chinese Medicines authentication, College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China
Hongbao Liang: Lunan Pharmaceutical Group Co., Ltd., State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Linyi, China
Xuzhen Lv: Teaching and Research Office of Chinese Medicines authentication, College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China
Fengtang Jing: Teaching and Research Office of Chinese Medicines authentication, College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China
Lu Qin: Teaching and Research Office of Chinese Medicines authentication, College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China
Tianlun Zhao: Teaching and Research Office of Chinese Medicines authentication, College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China
Chenxi Wang: Teaching and Research Office of Chinese Medicines authentication, College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China
Guangxu Liu: Teaching and Research Office of Chinese Medicines authentication, College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China
Shuai Feng: Teaching and Research Office of Chinese Medicines authentication, College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China
Feng Li: Teaching and Research Office of Chinese Medicines authentication, College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China

DOI: https://doi.org/10.3389/fchem.2022.888673
Journal volume & issue: Vol. 10

Abstract

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Chicoric acid has been widely used in food, medicine, animal husbandry, and other commercial products because of its significant pharmacological activities. However, the shortage of chicoric acid limits its further development and utilization. Currently, Echinacea purpurea (L.) Moench serves as the primary natural resource of chicoric acid, while other sources of it are poorly known. Extracting chicoric acid from plants is the most common approach. Meanwhile, chicoric acid levels vary in different plants as well as in the same plant from different areas and different medicinal parts, and different extraction methods. We comprehensively reviewed the information regarding the sources of chicoric acid from plant extracts, its chemical synthesis, biosynthesis, and bioactive effects.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

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