Agar-tragacanth/silk fibroin hydrogel containing Zn-based MOF as a novel nanobiocomposite with biological activity

Farnaz Lalebeigi; Amir Kashtiaray; Hooman Aghamirza Moghim Aliabadi; Fatemeh Moghadaskhou; Zeinab Pajoum; Seyede Mehrnoush Nokandeh; Mohammad Mahdavi; Reza Eivazzadeh-Keihan; Ali Maleki

doi:10.1038/s41598-024-61329-3

Scientific Reports (May 2024)

Agar-tragacanth/silk fibroin hydrogel containing Zn-based MOF as a novel nanobiocomposite with biological activity

Farnaz Lalebeigi,
Amir Kashtiaray,
Hooman Aghamirza Moghim Aliabadi,
Fatemeh Moghadaskhou,
Zeinab Pajoum,
Seyede Mehrnoush Nokandeh,
Mohammad Mahdavi,
Reza Eivazzadeh-Keihan,
Ali Maleki

Affiliations

Farnaz Lalebeigi: Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology
Amir Kashtiaray: Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology
Hooman Aghamirza Moghim Aliabadi: Medical Biotechnology Department, Biotechnology Research Center (BRC), Pasteur Institute of Iran (IPI)
Fatemeh Moghadaskhou: Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology
Zeinab Pajoum: Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology
Seyede Mehrnoush Nokandeh: Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology
Mohammad Mahdavi: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences
Reza Eivazzadeh-Keihan: Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology
Ali Maleki: Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology

DOI: https://doi.org/10.1038/s41598-024-61329-3
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 12

Abstract

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Abstract In this study, a novel nanobiocomposite consisting of agar (Ag), tragacanth gum (TG), silk fibroin (SF), and MOF-5 was synthesized and extensively investigated by various analytical techniques and basic biological assays for potential biomedical applications. The performed Trypan blue dye exclusion assay indicated that the proliferation percentage of HEK293T cells was 71.19%, while the proliferation of cancer cells (K-562 and MCF-7) was significantly lower, at 10.74% and 3.33%. Furthermore, the Ag-TG hydrogel/SF/MOF-5 nanobiocomposite exhibited significant antimicrobial activity against both E. coli and S. aureus strains, with growth inhibition rates of 76.08% and 69.19% respectively. Additionally, the hemolytic index of fabricated nanobiocomposite was found approximately 19%. These findings suggest that the nanobiocomposite exhibits significant potential for application in cancer therapy and wound healing.

Published in Scientific Reports

ISSN: 2045-2322 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine; Science
Website: https://www.nature.com/srep/

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Abstract

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