Co-inhibition of ATM and ROCK synergistically improves cell proliferation in replicative senescence by activating FOXM1 and E2F1

Eun Jae Yang; Ji Hwan Park; Hyun-Ji Cho; Jeong-A Hwang; Seung-Hwa Woo; Chi Hyun Park; Sung Young Kim; Joon Tae Park; Sang Chul Park; Daehee Hwang; Young-Sam Lee

doi:10.1038/s42003-022-03658-5

Communications Biology (Jul 2022)

Co-inhibition of ATM and ROCK synergistically improves cell proliferation in replicative senescence by activating FOXM1 and E2F1

Eun Jae Yang,
Ji Hwan Park,
Hyun-Ji Cho,
Jeong-A Hwang,
Seung-Hwa Woo,
Chi Hyun Park,
Sung Young Kim,
Joon Tae Park,
Sang Chul Park,
Daehee Hwang,
Young-Sam Lee

Affiliations

Eun Jae Yang: Department of New Biology, DGIST
Ji Hwan Park: Department of New Biology, DGIST
Hyun-Ji Cho: Department of New Biology, DGIST
Jeong-A Hwang: Department of New Biology, DGIST
Seung-Hwa Woo: Department of New Biology, DGIST
Chi Hyun Park: Department of Computer Science and Engineering, Kangwon National University
Sung Young Kim: Department of Biochemistry, Konkuk University School of Medicine
Joon Tae Park: Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University
Sang Chul Park: Well Aging Research Center, Division of Biotechnology, DGIST
Daehee Hwang: Department of Biological Sciences, Seoul National University
Young-Sam Lee: Department of New Biology, DGIST

DOI: https://doi.org/10.1038/s42003-022-03658-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

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Inhibitors to ATM and ROCK kinases increases the proliferation via transcriptional changes in human diploid fibroblasts undergoing replicative senescence in a synergistic manner

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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