377 IL-15 treatment enhances the in vivo anti-tumor efficacy of sipuleucel-T by activating CD8+ T and NKT effector cells, augmenting tumor infiltration, and reversing immunoresistance pathways

• Bo Peng,
• Tuyen Vu,
• Nadeem Sheikh,
• Russell Pachynski,
• Brian Van Tine,
• Todd Fehniger,
• Kevin Kim,
• Muhammad A Saeed,
• Ariel Borkowski,
• Daniel Thorek

Affiliations

Bo Peng

Department of Ultrasonography, Mianzhu City People’s Hospital, Mianzhu, China

Tuyen Vu

Aff391 grid.62560.370000000403788294Harvard Medical School, Dana-Farber Cancer Center, and Brigham and Women’s Hospital Boston MA USA

Nadeem Sheikh

Aff9 grid.421886.10000 0004 0463 3147Dendreon Seattle WA USA

Russell Pachynski

7Washington University School of Medicine, St Louis, MO, USA

Brian Van Tine

7Washington University in St. Louis, St Louis, MO, USA

Todd Fehniger

2Washington University School of Medicine, St Louis, MO, USA

Kevin Kim

4San Francisco Oncology Associates, San Francisco, CA, USA

Muhammad A Saeed

1Washington University School of Medicine, St Louis, MO, USA

Ariel Borkowski

1Washington University School of Medicine, St Louis, MO, USA

Daniel Thorek

1Washington University School of Medicine, St Louis, MO, USA