Nature Communications (Oct 2018)
Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese
- Ruijuan Zheng,
- Zhiqiang Li,
- Fusheng He,
- Haipeng Liu,
- Jianhua Chen,
- Jiayu Chen,
- Xuefeng Xie,
- Juan Zhou,
- Hao Chen,
- Xiangyang Wu,
- Juehui Wu,
- Boyu Chen,
- Yahui Liu,
- Haiyan Cui,
- Lin Fan,
- Wei Sha,
- Yin Liu,
- Jiqiang Wang,
- Xiaochen Huang,
- Linfeng Zhang,
- Feifan Xu,
- Jie Wang,
- Yonghong Feng,
- Lianhua Qin,
- Hua Yang,
- Zhonghua Liu,
- Zhenglin Cui,
- Feng Liu,
- Xinchun Chen,
- Shaorong Gao,
- Silong Sun,
- Yongyong Shi,
- Baoxue Ge
Affiliations
- Ruijuan Zheng
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Zhiqiang Li
- The Affiliated Hospital of Qingdao University &The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University
- Fusheng He
- BGI Genomics, BGI-Shenzhen
- Haipeng Liu
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Jianhua Chen
- Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University
- Jiayu Chen
- Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University
- Xuefeng Xie
- BGI Genomics, BGI-Shenzhen
- Juan Zhou
- Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University
- Hao Chen
- Department of Microbiology and Immunology, Tongji University School of Medicine
- Xiangyang Wu
- Department of Microbiology and Immunology, Tongji University School of Medicine
- Juehui Wu
- Department of Microbiology and Immunology, Tongji University School of Medicine
- Boyu Chen
- Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University
- Yahui Liu
- Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University
- Haiyan Cui
- Tuberculosis Center for Diagnosis and Treatment, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Lin Fan
- Tuberculosis Center for Diagnosis and Treatment, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Wei Sha
- Tuberculosis Center for Diagnosis and Treatment, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Yin Liu
- Department of Clinical Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Jiqiang Wang
- Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University
- Xiaochen Huang
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Linfeng Zhang
- Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University
- Feifan Xu
- Clinical Laboratory, The Sixth People’s Hospital of Nantong
- Jie Wang
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Yonghong Feng
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Lianhua Qin
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Hua Yang
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Zhonghua Liu
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Zhenglin Cui
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Feng Liu
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- Xinchun Chen
- Shenzhen University School of Medicine
- Shaorong Gao
- Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University
- Silong Sun
- BGI Genomics, BGI-Shenzhen
- Yongyong Shi
- The Affiliated Hospital of Qingdao University &The Biomedical Sciences Institute of Qingdao University (Qingdao Branch of SJTU Bio-X Institutes), Qingdao University
- Baoxue Ge
- Shanghai Key Lab of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-06539-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
Genetic risk loci for tuberculosis (TB) have so far been identified in African and Russian populations. Here, the authors perform a three-stage GWAS for TB in Han Chinese populations and find two risk loci near ESRRB and TGM6 and further demonstrate that tgm6 protects mice from Mtb infection.
