Nature Communications (Feb 2020)
B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction
- Takafumi Minato,
- Satoru Nirasawa,
- Teruki Sato,
- Tomokazu Yamaguchi,
- Midori Hoshizaki,
- Tadakatsu Inagaki,
- Kazuhiko Nakahara,
- Tadashi Yoshihashi,
- Ryo Ozawa,
- Saki Yokota,
- Miyuki Natsui,
- Souichi Koyota,
- Taku Yoshiya,
- Kumiko Yoshizawa-Kumagaye,
- Satoru Motoyama,
- Takeshi Gotoh,
- Yoshikazu Nakaoka,
- Josef M. Penninger,
- Hiroyuki Watanabe,
- Yumiko Imai,
- Saori Takahashi,
- Keiji Kuba
Affiliations
- Takafumi Minato
- Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine
- Satoru Nirasawa
- Biological Resources and Post-harvest Division, Japan International Research Center for Agricultural Sciences
- Teruki Sato
- Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine
- Tomokazu Yamaguchi
- Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine
- Midori Hoshizaki
- Laboratory of Regulation of Intractable Infectious Diseases, National Institute of Biomedical Innovation, Health and Nutrition
- Tadakatsu Inagaki
- Department of Vascular Physiology, Research Institute National Cerebral and Cardiovascular Center
- Kazuhiko Nakahara
- Biological Resources and Post-harvest Division, Japan International Research Center for Agricultural Sciences
- Tadashi Yoshihashi
- Biological Resources and Post-harvest Division, Japan International Research Center for Agricultural Sciences
- Ryo Ozawa
- Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine
- Saki Yokota
- Department of Materials Science, Applied Chemistry Course, Graduate School of Engineering Science, Akita University
- Miyuki Natsui
- Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine
- Souichi Koyota
- Molecular Medicine Laboratory, Bioscience Education and Research Support Center, Akita University
- Taku Yoshiya
- Peptide Institute, Inc.
- Kumiko Yoshizawa-Kumagaye
- Peptide Institute, Inc.
- Satoru Motoyama
- Department of Surgery, Akita University Graduate School of Medicine
- Takeshi Gotoh
- Department of Materials Science, Applied Chemistry Course, Graduate School of Engineering Science, Akita University
- Yoshikazu Nakaoka
- Department of Vascular Physiology, Research Institute National Cerebral and Cardiovascular Center
- Josef M. Penninger
- IMBA -Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Campus Vienna BioCenter
- Hiroyuki Watanabe
- Department of Cardiovascular Medicine, Akita University Graduate School of Medicine
- Yumiko Imai
- Laboratory of Regulation of Intractable Infectious Diseases, National Institute of Biomedical Innovation, Health and Nutrition
- Saori Takahashi
- Akita Research Institute of Food and Brewing
- Keiji Kuba
- Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-14867-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
The enzyme ACE2 is involved in cardiac pathology and can counteract heart failure and other cardio-pulmonary diseases. Here the authors show that bacteria produce an ACE2-like enzyme that is effective in suppressing cardiac hypertrophy and fibrosis in mice.
