Preparation of Quinolinium Salts Differing in the Length of the Alkyl Side Chain

Abstract

Quaternary quinolinium salts differing in alkyl chain length are members of a widespread group of cationic surfactants. These compounds have numerous applications in various branches of industry and research. In this work, the preparation of quinoline-derived cationic surface active agents differing in the length of the side alkyl chains (from C₈ to C₂₀) is described. An HPLC method was successfully developed for distinction of all members of the series of prepared long-chain quinolinium derivatives. In conclusion, some possibilities of intended tests or usage have been summarized. <em>In vitro</em> testing using a microdilution broth method showed good activity of a substance with a C12 chain length against Gram-positive cocci and <em>Candida </em>species.

Keywords

• quinolinium salts
• synthesis
• HPLC
• surfactants
• detergents
• disinfectants
• &lt;em&gt;in vitro&lt;/em&gt; antimicrobial activity