Nature Communications (Nov 2019)

Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model

  • Sergio Valbuena,
  • Álvaro García,
  • Wilfrid Mazier,
  • Ana V. Paternain,
  • Juan Lerma

DOI
https://doi.org/10.1038/s41467-019-13004-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Exaggerated synaptic inhibition is hypothesised to be a main cause of cognitive deficits in Down syndrome models. The authors identify triplication of the kainate receptor encoding gene Grik1 as the cause of memory deficits due to a reorganization of synaptic inhibition along the CA1 dendritic tree.