Deciphering the Functional Long Non‐Coding RNAs Derived from MicroRNA Loci

Weiqian Li; Yue Huo; Yue Ren; Chenxi Han; Shuo Li; Kangning Wang; Manman He; Yiying Chen; Yanran Wang; Lingjie Xu; Yuehong Guo; Yanmin Si; Yufeng Gao; Jiayue Xu; Xiaoshuang Wang; Yanni Ma; Jia Yu; Fang Wang

doi:10.1002/advs.202203987

Advanced Science (Nov 2023)

Deciphering the Functional Long Non‐Coding RNAs Derived from MicroRNA Loci

Weiqian Li,
Yue Huo,
Yue Ren,
Chenxi Han,
Shuo Li,
Kangning Wang,
Manman He,
Yiying Chen,
Yanran Wang,
Lingjie Xu,
Yuehong Guo,
Yanmin Si,
Yufeng Gao,
Jiayue Xu,
Xiaoshuang Wang,
Yanni Ma,
Jia Yu,
Fang Wang

Affiliations

Weiqian Li: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Yue Huo: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Yue Ren: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Chenxi Han: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Shuo Li: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Kangning Wang: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Manman He: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Yiying Chen: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Yanran Wang: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Lingjie Xu: Emergency Department of West China Hospital Sichuan University Chengdu 610041 P.R. China
Yuehong Guo: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Yanmin Si: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Yufeng Gao: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Jiayue Xu: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Xiaoshuang Wang: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Yanni Ma: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Jia Yu: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China
Fang Wang: State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Haihe Laboratory of Cell Ecosystem The Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences / Peking Union Medical College Beijing 100005 P.R. China

DOI: https://doi.org/10.1002/advs.202203987
Journal volume & issue: Vol. 10, no. 33
pp. n/a – n/a

Abstract

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Abstract Albeit the majority of eukaryotic genomes can be pervasively transcribed to a diverse population of lncRNAs and various subtypes of lncRNA are discovered. However, the genome‐wide study of miRNA‐derived lncRNAs is still lacking. Here, it is reported that over 800 miRNA gene‐originated lncRNAs (molncRNAs) are generated from miRNA loci. One of them, molnc‐301b from miR‐301b and miR‐130b, functions as an “RNA decoy” to facilitate dissociation of the chromatin remodeling protein SMARCA5 from chromatin and thereby sequester transcription and mRNA translation. Specifically, molnc‐301b attenuates erythropoiesis by mitigating the transcription of erythropoietic and translation‐associated genes, such as GATA1 and FOS. In addition, a useful and powerful CRISPR screen platform to characterize the biological functions of molncRNAs at large‐scale and single‐cell levels is established and 29 functional molncRNAs in hematopoietic cells are identified. Collectively, the focus is on miRNA‐derived lncRNAs, deciphering their landscape during normal hematopoiesis, and comprehensively evaluating their potential roles.

Published in Advanced Science

ISSN: 2198-3844 (Online)
Publisher: Wiley
Country of publisher: Germany
LCC subjects: Science
Website: https://onlinelibrary.wiley.com/journal/21983844

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