Frontiers in Psychiatry (Mar 2022)
Regressive Autism Spectrum Disorder: High Levels of Total Secreted Amyloid Precursor Protein and Secreted Amyloid Precursor Protein-α in Plasma
- Xiaoli Li,
- Xiaoli Li,
- Xiaoli Li,
- Xiaoli Li,
- Xiaoli Li,
- Ping Zhou,
- Ping Zhou,
- Ping Zhou,
- Ping Zhou,
- Ping Zhou,
- Qiu Li,
- Qiu Li,
- Qiu Li,
- Qiu Li,
- Bin Peng,
- Yupeng Cun,
- Yupeng Cun,
- Yupeng Cun,
- Ying Dai,
- Ying Dai,
- Ying Dai,
- Ying Dai,
- Ying Dai,
- Hua Wei,
- Hua Wei,
- Hua Wei,
- Hua Wei,
- Hua Wei,
- Xiao Liu,
- Xiao Liu,
- Xiao Liu,
- Xiao Liu,
- Xiao Liu,
- Yang Yu,
- Yang Yu,
- Zhiyang Jiang,
- Zhiyang Jiang,
- Zhiyang Jiang,
- Zhiyang Jiang,
- Zhiyang Jiang,
- Qiongli Fan,
- Yuping Zhang,
- Ting Yang,
- Ting Yang,
- Ting Yang,
- Ting Yang,
- Ting Yang,
- Jie Chen,
- Jie Chen,
- Jie Chen,
- Jie Chen,
- Jie Chen,
- Qian Cheng,
- Qian Cheng,
- Qian Cheng,
- Qian Cheng,
- Qian Cheng,
- Tingyu Li,
- Tingyu Li,
- Tingyu Li,
- Tingyu Li,
- Tingyu Li,
- Li Chen,
- Li Chen,
- Li Chen,
- Li Chen,
- Li Chen
Affiliations
- Xiaoli Li
- Growth, Development, and Mental Health of Children and Adolescence Center, Children's Hospital of Chongqing Medical University, Chongqing, China
- Xiaoli Li
- Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China
- Xiaoli Li
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Xiaoli Li
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Xiaoli Li
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Ping Zhou
- Growth, Development, and Mental Health of Children and Adolescence Center, Children's Hospital of Chongqing Medical University, Chongqing, China
- Ping Zhou
- Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China
- Ping Zhou
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Ping Zhou
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Ping Zhou
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Qiu Li
- Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China
- Qiu Li
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Qiu Li
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Qiu Li
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Bin Peng
- School of Public Health and Management, Department of Health Statistics, Chongqing Medical University, Chongqing, China
- Yupeng Cun
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Yupeng Cun
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Yupeng Cun
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Ying Dai
- Growth, Development, and Mental Health of Children and Adolescence Center, Children's Hospital of Chongqing Medical University, Chongqing, China
- Ying Dai
- Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China
- Ying Dai
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Ying Dai
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Ying Dai
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Hua Wei
- Growth, Development, and Mental Health of Children and Adolescence Center, Children's Hospital of Chongqing Medical University, Chongqing, China
- Hua Wei
- Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China
- Hua Wei
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Hua Wei
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Hua Wei
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Xiao Liu
- Growth, Development, and Mental Health of Children and Adolescence Center, Children's Hospital of Chongqing Medical University, Chongqing, China
- Xiao Liu
- Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China
- Xiao Liu
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Xiao Liu
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Xiao Liu
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Yang Yu
- Growth, Development, and Mental Health of Children and Adolescence Center, Children's Hospital of Chongqing Medical University, Chongqing, China
- Yang Yu
- Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China
- Zhiyang Jiang
- Growth, Development, and Mental Health of Children and Adolescence Center, Children's Hospital of Chongqing Medical University, Chongqing, China
- Zhiyang Jiang
- Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China
- Zhiyang Jiang
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Zhiyang Jiang
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Zhiyang Jiang
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Qiongli Fan
- Department of Pediatrics, Xinqiao Hospital, Army Medical University, Chongqing, China
- Yuping Zhang
- Department of Pediatrics, Xinqiao Hospital, Army Medical University, Chongqing, China
- Ting Yang
- Growth, Development, and Mental Health of Children and Adolescence Center, Children's Hospital of Chongqing Medical University, Chongqing, China
- Ting Yang
- Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China
- Ting Yang
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Ting Yang
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Ting Yang
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Jie Chen
- Growth, Development, and Mental Health of Children and Adolescence Center, Children's Hospital of Chongqing Medical University, Chongqing, China
- Jie Chen
- Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China
- Jie Chen
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Jie Chen
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Jie Chen
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Qian Cheng
- Growth, Development, and Mental Health of Children and Adolescence Center, Children's Hospital of Chongqing Medical University, Chongqing, China
- Qian Cheng
- Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China
- Qian Cheng
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Qian Cheng
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Qian Cheng
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Tingyu Li
- Growth, Development, and Mental Health of Children and Adolescence Center, Children's Hospital of Chongqing Medical University, Chongqing, China
- Tingyu Li
- Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China
- Tingyu Li
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Tingyu Li
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Tingyu Li
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- Li Chen
- Growth, Development, and Mental Health of Children and Adolescence Center, Children's Hospital of Chongqing Medical University, Chongqing, China
- Li Chen
- Chongqing Key Laboratory of Child Health and Nutrition, Chongqing, China
- Li Chen
- Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, China
- Li Chen
- China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China
- Li Chen
- National Clinical Research Center for Child Health and Disorders, Chongqing, China
- DOI
- https://doi.org/10.3389/fpsyt.2022.809543
- Journal volume & issue
-
Vol. 13
Abstract
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication difficulties, repetitive behaviors, and parochial interests. Individuals with regressive ASD (RA), a unique subtype, have poor outcomes. Moreover, there are currently no validated blood-based biomarkers for ASD, hindering early diagnosis and treatment. This study was the first to examine plasma levels of total secreted amyloid precursor protein (sAPPtotal), secreted amyloid precursor protein-α (sAPPα), and secreted amyloid precursor protein-β (sAPPβ) in children diagnosed with RA (n = 23) and compare them with the levels in age-matched children with non-regressive ASD (NRA) (n = 23) and typically developing (TD) controls (n = 23). We found that sAPPtotal and sAPPα levels were significantly higher in children with RA than in children with NRA or in TD controls. In contrast, no difference was observed in sAPPβ levels. In conclusion, increased plasma levels of sAPPtotal and sAPPα may be valuable biomarkers for the early identification of ASD regression. Prospective studies will be conducted using a larger sample to further investigate these differences.
Keywords
