Nature Communications (May 2021)
Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency
- Seula Shin,
- Hao Zhou,
- Chenxi He,
- Yanjun Wei,
- Yunfei Wang,
- Takashi Shingu,
- Ailiang Zeng,
- Shaobo Wang,
- Xin Zhou,
- Hongtao Li,
- Qiang Zhang,
- Qinling Mo,
- Jiafu Long,
- Fei Lan,
- Yiwen Chen,
- Jian Hu
Affiliations
- Seula Shin
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Hao Zhou
- State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University
- Chenxi He
- Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan University
- Yanjun Wei
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Yunfei Wang
- Clinical Science Division, H. Lee Moffitt Cancer Center & Research Institute
- Takashi Shingu
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Ailiang Zeng
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Shaobo Wang
- Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University
- Xin Zhou
- Cancer Research Institute of Jilin University, The First Hospital of Jilin University
- Hongtao Li
- Department of Oncology, Affiliated Sixth People’s Hospital, Shanghai Jiaotong University
- Qiang Zhang
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- Qinling Mo
- State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University
- Jiafu Long
- State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University
- Fei Lan
- Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan University
- Yiwen Chen
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Jian Hu
- Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-22782-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
Eye lens cells are highly enriched in cholesterol that sustains lens transparency, and disruption of cholesterol biosynthesis leads to cataracts. The authors show that cholesterol biosynthesis regulated by Qki is essential for maintenance of membrane integrity of lens cells and proper protein folding.
