Immunological Study for Interleukin-5 and GM-CSF for Complications Post-Wisdom Teeth Extraction

Abstract

Background:Wisdom teeth extraction is one of the most common operations conducted in dental clinics and the most common duty performed in oral and maxillofacial surgery clinics. Complications from this treatment are common, including dry socket, postoperative discomfort, delayed healing, postoperative infection, hematoma, edema, and trismus. Objectives:The purpose of this study is to quantify the proinflammatory interleukin-5 (IL-5) and granulocyte-macrophage colony-stimulating factor before extraction in saliva by ELIZA technique from patients who visit the clinic to extract wisdom tooth to study its impact on problems following extraction. Materials and Methods:A total of 100 saliva study samples (50 cases and 50 control), 44 males and 56 females, aged 19–65 years, were referred to the surgical clinic, College of Dentistry, University of Babylon specialized dentistry centers, and private clinics in Hillah city, Iraq, to determine the levels of preoperative IL-5 and GM-CSF by ELIZA technique. Results:There were no major differences between females and males in both groups, according to the findings of this study. In comparison to the healthy subjects, however, patients showed higher significant differences in measuring (IL-5) and (GM-CSF) concentrations (366.81 ± 17.8, 12.26 ± 1.3) (P ≤ 0.05) by using the ROC test IL-5 and GM-CSF showed (cutoff 146.42, sensitivity 90%, specificity 82%), (cutoff 4.04, sensitivity 84%, specificity 72%). Conclusion:proinflammatory IL-5 and GM-CSF were shown to be higher in patients with complications following wisdom teeth extraction than it was in control; highly level of IL-5 and GM-CSF may Predict complications following extraction.

Keywords

• complications
• extraction
• gm-csf
• il-5
• wisdom tooth