ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling

Matteo Gentili; Bingxu Liu; Malvina Papanastasiou; Deborah Dele-Oni; Marc A. Schwartz; Rebecca J. Carlson; Aziz M. Al’Khafaji; Karsten Krug; Adam Brown; John G. Doench; Steven A. Carr; Nir Hacohen

doi:10.1038/s41467-023-36132-9

Nature Communications (Feb 2023)

ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling

Matteo Gentili,
Bingxu Liu,
Malvina Papanastasiou,
Deborah Dele-Oni,
Marc A. Schwartz,
Rebecca J. Carlson,
Aziz M. Al’Khafaji,
Karsten Krug,
Adam Brown,
John G. Doench,
Steven A. Carr,
Nir Hacohen

Affiliations

Matteo Gentili: Broad Institute of MIT and Harvard
Bingxu Liu: Broad Institute of MIT and Harvard
Malvina Papanastasiou: Broad Institute of MIT and Harvard
Deborah Dele-Oni: Broad Institute of MIT and Harvard
Marc A. Schwartz: Broad Institute of MIT and Harvard
Rebecca J. Carlson: Broad Institute of MIT and Harvard
Aziz M. Al’Khafaji: Broad Institute of MIT and Harvard
Karsten Krug: Broad Institute of MIT and Harvard
Adam Brown: Broad Institute of MIT and Harvard
John G. Doench: Broad Institute of MIT and Harvard
Steven A. Carr: Broad Institute of MIT and Harvard
Nir Hacohen: Broad Institute of MIT and Harvard

DOI: https://doi.org/10.1038/s41467-023-36132-9
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 22

Abstract

Read online

STING is an intracellular sensor of pathogen- or host-derived DNA. In this study, the authors identify an ESCRT complex that regulates STING degradation, thus acting as a homeostatic regulator of STING signalling and type-I interferon responses.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal