New link between the RNA polymerase II-CTD and replication stress

Abstract

Conflicts between transcription and replication are a major source of replication stress. Our recent findings show that proper dephosphorylation of Serine 5 in the carboxy-terminal domain (CTD) of DNA-directed RNA polymerase II subunit RPB1 is needed to prevent such conflicts in human cells.

Keywords

• replication stress
• transcription-replication conflicts
• pp1 phosphatase
• rna polymerase ii
• pp1 nuclear targeting subunit (pnuts)
• carboxy-terminal domain (ctd)
• wd repeat-containing protein 82 (wdr82)