<b>Levan in the developing of new colon-specific polymer material: evaluation of the permeability, moisture and thermal analyses in free films of Eudragit^® FS 30 D</b> - doi 10.4025/actascihealthsci.v34i2.11729

Abstract

Levan was used as agent in the synthesis of new colon-specific polymeric matrix together with Eudragit® FS 30 D. Eudragit® FS 30 D films incorporated with levan were made by casting process and characterized to: water vapour transmission, sweeling index, differential scanning calorimetry and thermogravimetric. The levan increased the films permeability (p 0.05). The thermal analyses of the films indicated a glass transition temperature approximate at 47°C and thermal decomposition at 400°C. The results indicated that there is potential for using such site-specificity blend as pharmaceutical coating material.

Keywords

• coating material
• colon-specific release
• physicochemical characterization
• thermal analysis