Hemoglobin in the blood acts as a chemosensory signal via the mouse vomeronasal system

Takuya Osakada; Takayuki Abe; Takumi Itakura; Hiromi Mori; Kentaro K. Ishii; Ryo Eguchi; Ken Murata; Kosuke Saito; Sachiko Haga-Yamanaka; Hiroko Kimoto; Yoshihiro Yoshihara; Kazunari Miyamichi; Kazushige Touhara

doi:10.1038/s41467-022-28118-w

Nature Communications (Feb 2022)

Hemoglobin in the blood acts as a chemosensory signal via the mouse vomeronasal system

Takuya Osakada,
Takayuki Abe,
Takumi Itakura,
Hiromi Mori,
Kentaro K. Ishii,
Ryo Eguchi,
Ken Murata,
Kosuke Saito,
Sachiko Haga-Yamanaka,
Hiroko Kimoto,
Yoshihiro Yoshihara,
Kazunari Miyamichi,
Kazushige Touhara

Affiliations

Takuya Osakada: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Takayuki Abe: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Takumi Itakura: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Hiromi Mori: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Kentaro K. Ishii: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Ryo Eguchi: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Ken Murata: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Kosuke Saito: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Sachiko Haga-Yamanaka: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Hiroko Kimoto: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Yoshihiro Yoshihara: ERATO Touhara Chemosensory Signal Project, JST, The University of Tokyo
Kazunari Miyamichi: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Kazushige Touhara: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-022-28118-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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The vomeronasal system regulates sensing of various environmental cues. Here, the authors show that exposure to hemoglobin results in the activation of Vmn2r88+ vomeronasal sensory neurons in both male and female mice. However, exposure to hemoglobin enhances digging and rearing behaviour in lactating female mice only.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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