Nature Communications (Feb 2022)

Small Cajal body-associated RNA 2 (scaRNA2) regulates DNA repair pathway choice by inhibiting DNA-PK

  • Sofie Bergstrand,
  • Eleanor M. O’Brien,
  • Christos Coucoravas,
  • Dominika Hrossova,
  • Dimitra Peirasmaki,
  • Sandro Schmidli,
  • Soniya Dhanjal,
  • Chiara Pederiva,
  • Lee Siggens,
  • Oliver Mortusewicz,
  • Julienne J. O’Rourke,
  • Marianne Farnebo

DOI
https://doi.org/10.1038/s41467-022-28646-5
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

Read online

Proper repair of DNA double-strand breaks is essential for genomic stability. Here, the authors report that a long non-coding RNA, scaRNA2, inhibits DNA-PK and thereby regulates the choice between error-prone NHEJ and error-free HR DNA repair.