Nature Communications (Sep 2021)
Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B
- Maximilian Y. Deng,
- Dominik Sturm,
- Elke Pfaff,
- Martin Sill,
- Damian Stichel,
- Gnana Prakash Balasubramanian,
- Stephan Tippelt,
- Christof Kramm,
- Andrew M. Donson,
- Adam L. Green,
- Chris Jones,
- Jens Schittenhelm,
- Martin Ebinger,
- Martin U. Schuhmann,
- Barbara C. Jones,
- Cornelis M. van Tilburg,
- Andrea Wittmann,
- Andrey Golanov,
- Marina Ryzhova,
- Jonas Ecker,
- Till Milde,
- Olaf Witt,
- Felix Sahm,
- David Reuss,
- David Sumerauer,
- Josef Zamecnik,
- Andrey Korshunov,
- Andreas von Deimling,
- Stefan M. Pfister,
- David T. W. Jones
Affiliations
- Maximilian Y. Deng
- Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
- Dominik Sturm
- Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
- Elke Pfaff
- Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
- Martin Sill
- Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
- Damian Stichel
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- Gnana Prakash Balasubramanian
- Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
- Stephan Tippelt
- Department of Pediatric Oncology and Hematology, Essen University Hospital
- Christof Kramm
- Division of Pediatric Hematology and Oncology, University Medical Center Goettingen
- Andrew M. Donson
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado School of Medicine
- Adam L. Green
- Morgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado School of Medicine
- Chris Jones
- Division of Molecular Pathology and Division of Cancer Therapeutics, The Institute of Cancer Research
- Jens Schittenhelm
- Department of Neuropathology, Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen-Stuttgart, Tübingen University Hospital
- Martin Ebinger
- Department of Pediatric Hematology/Oncology, Children’s University Hospital
- Martin U. Schuhmann
- Department of Neurosurgery, Division of Pediatric Neurosurgery, Tübingen University Hospital
- Barbara C. Jones
- Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
- Cornelis M. van Tilburg
- Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
- Andrea Wittmann
- Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
- Andrey Golanov
- Department of Neuropathology, NN Burdenko Neurosurgical Institute
- Marina Ryzhova
- Department of Neuropathology, NN Burdenko Neurosurgical Institute
- Jonas Ecker
- Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
- Till Milde
- Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
- Olaf Witt
- Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
- Felix Sahm
- Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
- David Reuss
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- David Sumerauer
- Department of Pediatric Hematology and Oncology, Motol University Hospital, Charles University
- Josef Zamecnik
- Department of Pathology, Motol University Hospital, Charles University
- Andrey Korshunov
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- Andreas von Deimling
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- Stefan M. Pfister
- Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
- David T. W. Jones
- Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital and German Cancer Resarch Center (DKFZ)
- DOI
- https://doi.org/10.1038/s41467-021-25708-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies but their origin are still unclear. Here, the authors define the genomic, epigenetic and transcriptional landscape of 32 RIGs cases.
