Nature Communications (Dec 2020)
Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer
- Sanja Pajovic,
- Robert Siddaway,
- Taylor Bridge,
- Javal Sheth,
- Patricia Rakopoulos,
- Byungjin Kim,
- Scott Ryall,
- Sameer Agnihotri,
- Lauren Phillips,
- Man Yu,
- Christopher Li,
- Scott Milos,
- Palak Patel,
- Dilakshan Srikanthan,
- Annie Huang,
- Cynthia Hawkins
Affiliations
- Sanja Pajovic
- Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Robert Siddaway
- Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Taylor Bridge
- Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Javal Sheth
- Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Patricia Rakopoulos
- Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Byungjin Kim
- Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Scott Ryall
- Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Sameer Agnihotri
- Department of Neurological Surgery, Children’s Hospital of Pittsburgh of UPMC
- Lauren Phillips
- Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Man Yu
- Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Christopher Li
- Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Scott Milos
- Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Palak Patel
- Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Dilakshan Srikanthan
- Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Annie Huang
- Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Cynthia Hawkins
- Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- DOI
- https://doi.org/10.1038/s41467-020-19972-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Histone H3 at lysine 27 (H3K27M) is often mutated in cancer but its role in tumour initiation is unclear. Here, the authors generated a transgenic model expressing H3.3K27M from the Fabp7 gene promoter, demonstrating that H3.3K27M can initiate diverse tumorigesis on its own, acting through a RAS/MYC transcriptomic programme.
