Capabilities of capillary electrophoresis for analysis of ready-to-use pharmaceutical products with an antibacterial effect

Abstract

The capability to monitor quality of ready-to-use pharmaceuticals using capillary electrophoresis methods is evaluated in the paper. Optimal conditions for separation and determination of different classes of such antibacterial agents as penicillins, fluoroquinolones, nitrofurans, sulfanilamides, metronidazole and chloramphenicol are chosen. The range of content of active constituents is 1-2500 mg/g for solid samples and 0,001-0,50% for liquid preparations.

Keywords

• готовые лекарственные средства
• капиллярный зонный электрофорез
• мицеллярная электрокинетическая хроматография
• антибиотики
• антибактериальные вещества
• ready-to-use pharmaceuticals
• capillary zone electrophoresis
• micellar electrokinetic chromatography
• antibiotics
• antibacterial agents