PQM-1 controls hypoxic survival via regulation of lipid metabolism

Thomas Heimbucher; Julian Hog; Piyush Gupta; Coleen T. Murphy

doi:10.1038/s41467-020-18369-w

Nature Communications (Oct 2020)

PQM-1 controls hypoxic survival via regulation of lipid metabolism

Thomas Heimbucher,
Julian Hog,
Piyush Gupta,
Coleen T. Murphy

Affiliations

Thomas Heimbucher: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Julian Hog: Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg
Piyush Gupta: Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg
Coleen T. Murphy: Lewis-Sigler Institute for Integrative Genomics, Princeton University

DOI: https://doi.org/10.1038/s41467-020-18369-w
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Animals respond to hypoxic stress by adjusting metabolic processes to balance survival and reproduction. Here the authors identify the transcription factor PQM-1 as a metabolic regulator that balances hypoxic lipid and carbohydrate metabolism in C. elegans to limit somatic integrity and promote progeny survival.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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