Cancer Management and Research (Nov 2021)

Gut Microbiota: A Potential Target for Cancer Interventions

  • Zhou H,
  • Yuan Y,
  • Wang H,
  • Xiang W,
  • Li S,
  • Zheng H,
  • Wen Y,
  • Ming Y,
  • Chen L,
  • Zhou J

Journal volume & issue
Vol. Volume 13
pp. 8281 – 8296

Abstract

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Hu Zhou,1,2,* Yuan Yuan,1– 3,* Haorun Wang,1,2 Wei Xiang,1,2 shenjie Li,1,2 Haowen Zheng,1,2 Yuqi Wen,1,2 Yang Ming,1,2 Ligang Chen,1,2,4,5 Jie Zhou1,2,4,5 1Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China; 2Sichuan Clinical Research Center for Neurosurgery, Luzhou, Sichuan, People’s Republic of China; 3Department of Operation and Anaesthesia, Yibin First People’s Hospital, Yibin, Sichuan, People’s Republic of China; 4Academician (Expert) Workstation of Sichuan Province, Luzhou, Sichuan, People’s Republic of China; 5Neurological Diseases and Brain Function Laboratory, Luzhou, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jie Zhou Email [email protected]: The gut microbiota plays a crucial role in many physiological processes in the human body. Dysbiosis can disrupt the intestinal barrier and alter metabolism and immune responses, leading to the development of diseases. Over the past few decades, evidence has accumulated linking changes in the composition of the gut microbiota to dozens of seemingly unrelated conditions, including cancer. Overall, the gut microbiota mainly affects the occurrence and development of cancer by damaging host DNA, forming and maintaining a pro-inflammatory environment, and affecting host immune responses. In addition, the gut microbiota can also affect the efficacy and toxicity of chemotherapy, radiotherapy, and immunotherapy. Scientists attempt to improve the efficacy and decrease the toxicity of these treatment modalities by fine-tuning the gut microbiota. The aim of this review is to assist researchers and clinicians in developing new strategies for the detection and treatment of tumors by providing the latest information on the intestinal microbiome and cancer, as well as exploring potential application prospects and mechanisms of action.Keywords: intestinal flora, carcinogenesis, mechanism, therapy, fecal bacteria transplantation

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