Acoustical Studies of Molecular Interactions in the Solution of Streptomycin Drug at Different Temperatures and Concentrations

Abstract

Streptomycin is an antibiotic medication used to treat a number of bacterial infections. In the present study ultrasonic velocity (U), density (ρ) and viscosity (η) have been measured at frequency 1 MHz in the binary mixtures. The binary mixtures of streptomycin with water in the concentration range (0.1 to 0.0125%) at 303 K, 308 K, and 313 K using a multifrequency ultrasonic interferometer. The measured value of ultrasonic velocity, density and viscosity have been used to estimate the acoustical parameters namely adiabatic compressibility (βa), relaxation time (τ), acoustic impedance (z), free length (Lf), free volume (Vf) and internal pressure (Pi), Wada’s constant(W), Rao’s constant (R) to investigate the nature and strength of molecular interaction in the binary mixture with water. The obtained results support the occurrence of complex formation, molecular association through intermolecular hydrogen bonding in the binary liquid mixtures. DOI: http://dx.doi.org/10.17807/orbital.v13i4.1465

Keywords

• streptomycin
• free volume
• acoustical parameters
• ultrasonic velocity
• adiabatic compressibility
• acoustic impedance