A new approach to phosphorylation of nucleosides using oxyonium phosphobetaines as intermediates

Abstract

Oxyonium phosphobetaines are recently discovered molecules with a unique − O–P–O–N + bond system, which makes them useful and versatile intermediates for the synthesis of phosphates and their derivatives. In this paper, the preliminary data on the application of these compounds in nucleoside phosphorylation were presented.

Keywords

• synthesis
• phosphorylation
• n-oxides
• nucleotides
• oxyonium phosphobetaines
• h-phosphonates