Thoracic Cancer (Apr 2020)
Health‐related quality of life in patients with esophageal cancer or precancerous lesions assessed by EQ‐5D: A multicenter cross‐sectional study
- Youqing Wang,
- Jufang Shi,
- Lingbin Du,
- Huiyao Huang,
- Le Wang,
- Juan Zhu,
- Huizhang Li,
- Yana Bai,
- Xianzhen Liao,
- Ayan Mao,
- Guoxiang Liu,
- Jiansong Ren,
- Xiaojie Sun,
- Jiyong Gong,
- Qi Zhou,
- Ling Mai,
- Lin Zhu,
- Xiaojing Xing,
- Yuqin Liu,
- Ying Ren,
- Bingbing Song,
- Li Lan,
- Jinyi Zhou,
- Peian Lou,
- Xiaohua Sun,
- Xiao Qi,
- Shouling Wu,
- Wenqiang Wei,
- Kai Zhang,
- Min Dai,
- Wanqing Chen,
- Jie He
Affiliations
- Youqing Wang
- Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences/Department of Cancer Prevention, Cancer Hospital of the University of Chinese Academy of Sciences/Department of Cancer Prevention Zhejiang Cancer Hospital Hangzhou China
- Jufang Shi
- Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
- Lingbin Du
- Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences/Department of Cancer Prevention, Cancer Hospital of the University of Chinese Academy of Sciences/Department of Cancer Prevention Zhejiang Cancer Hospital Hangzhou China
- Huiyao Huang
- Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
- Le Wang
- Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences/Department of Cancer Prevention, Cancer Hospital of the University of Chinese Academy of Sciences/Department of Cancer Prevention Zhejiang Cancer Hospital Hangzhou China
- Juan Zhu
- Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
- Huizhang Li
- Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences/Department of Cancer Prevention, Cancer Hospital of the University of Chinese Academy of Sciences/Department of Cancer Prevention Zhejiang Cancer Hospital Hangzhou China
- Yana Bai
- Institute of Epidemiology and Health Statistics Lanzhou University Lanzhou China
- Xianzhen Liao
- Hunan Office for Cancer Control and Research Hunan Provincial Cancer Hospital Changsha China
- Ayan Mao
- Public Health Information Research Office, Institute of Medical Information Chinese Academy of Medical Sciences Beijing China
- Guoxiang Liu
- Department of Health Economics, School of Health Management Harbin Medical University Harbin China
- Jiansong Ren
- Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
- Xiaojie Sun
- Center for Health Management and Policy, Key Lab of Health Economics and Policy Shandong University Jinan China
- Jiyong Gong
- Science and Education Department of Public Health Division Shandong Tumor Hospital Jinan China
- Qi Zhou
- Chongqing Office for Cancer Control and Research Chongqing Cancer Hospital Chongqing China
- Ling Mai
- Department of Institute of Tumor Research Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital Zhengzhou China
- Lin Zhu
- Teaching and Research Department Affiliated Cancer Hospital of Xinjiang Medical University Urumqi China
- Xiaojing Xing
- Liaoning Office for Cancer Control and Research Liaoning Cancer Hospital & Institute Shenyang China
- Yuqin Liu
- Cancer Epidemiology Research Center Gansu Provincial Cancer Hospital Lanzhou China
- Ying Ren
- Urban Office of Cancer Early Detection and Treatment Tieling Central Hospital Tieling China
- Bingbing Song
- Heilongjiang Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University Harbin China
- Li Lan
- Institute of Chronic Disease Prevention and Control Harbin Center for Disease Control and Prevention Harbin China
- Jinyi Zhou
- Institute of Chronic Non‐communicable Diseases Prevention and Control Jiangsu Provincial Center for Disease Control and Prevention Nanjing China
- Peian Lou
- Department of Control and Prevention of Chronic Non‐Communicable Diseases Xuzhou Center for Disease Control and Prevention Xuzhou China
- Xiaohua Sun
- Ningbo Clinical Cancer Prevention Guidance Center Ningbo No.2 Hospital Ningbo China
- Xiao Qi
- Department of Occupational Medicine Tangshan People's Hospital Tangshan China
- Shouling Wu
- Health Department of Kailuan Group Kailuan General Hospital Tangshan China
- Wenqiang Wei
- Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
- Kai Zhang
- Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
- Min Dai
- Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
- Wanqing Chen
- Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
- Jie He
- Office of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China
- DOI
- https://doi.org/10.1111/1759-7714.13368
- Journal volume & issue
-
Vol. 11,
no. 4
pp. 1076 – 1089
Abstract
Background We aimed to obtain a set of health state utility scores of patients with esophageal cancer (EC) and precancerous lesions in China, and to explore the influencing factors of health‐related quality of life (HRQoL). Methods A hospital‐based multicenter cross‐sectional study was conducted. From 2013 to 2014, patients with EC or precancerous lesions were enrolled. HRQoL was assessed using a European quality of life‐5 dimension (EQ‐5D‐3L) instrument. Multivariable linear regression analysis was performed to explore the influencing factors of the EQ‐5D utility scores. Results A total of 2090 EC patients and 156 precancer patients were included in the study. The dimension of pain/discomfort had the highest rate of self‐reported problems, 60.5% in EC and 51.3% in precancer patients. The mean visual analog scale (VAS) score for EC and precancer patients were 68.4 ± 0.7 and 64.5 ± 3.1, respectively. The EQ‐5D utility scores for EC and precancer patients were estimated as 0.748 ± 0.009 and 0.852 ± 0.022, and the scores of EC at stage I, stage II, stage III, and stage IV were 0.693 ± 0.031, 0.747 ± 0.014, 0.762 ± 0.015, and 0.750 ± 0.023, respectively. According to the multivariable analyses, the factors of region, occupation, household income in 2012, health care insurance type, pathological type, type of therapy, and time points of the survey were statistically associated with the EQ‐5D utility scores of EC patients. Conclusions There were remarkable decrements of utility scores among esophageal cancer patients, compared with precancer patients. The specific utility scores of EC would support further cost‐utility analysis in populations in China.
Keywords
- EQ‐5D‐3L
- esophageal cancer
- health state utility
- health‐related quality of life
- multivariable linear regression
