Placental H3K27me3 establishes female resilience to prenatal insults

Bridget M. Nugent; Carly M. O’Donnell; C. Neill Epperson; Tracy L. Bale

doi:10.1038/s41467-018-04992-1

Nature Communications (Jul 2018)

Placental H3K27me3 establishes female resilience to prenatal insults

Bridget M. Nugent,
Carly M. O’Donnell,
C. Neill Epperson,
Tracy L. Bale

Affiliations

Bridget M. Nugent: Department of Pharmacology, University of Maryland School of Medicine Health Sciences Facility
Carly M. O’Donnell: Department of Biomedical Sciences, University of Pennsylvania 380 S. University Ave
C. Neill Epperson: Department of Psychiatry, University of Pennsylvania
Tracy L. Bale: Department of Pharmacology, University of Maryland School of Medicine Health Sciences Facility

DOI: https://doi.org/10.1038/s41467-018-04992-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Sex differences in placental O-linked N-acetylglucosamine transferase (OGT) activity mediate the effects of prenatal stress on neurodevelopmental programming. Here authors provide evidence that OGT confers variation in vulnerability to prenatal insults by establishing sex-specific trophoblast gene expression via regulation of H3K27me3.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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