Nature Communications (Aug 2016)
Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat
- Takahiro Seki,
- Kayoko Hosaka,
- Sharon Lim,
- Carina Fischer,
- Jennifer Honek,
- Yunlong Yang,
- Patrik Andersson,
- Masaki Nakamura,
- Erik Näslund,
- Seppo Ylä-Herttuala,
- Meili Sun,
- Hideki Iwamoto,
- Xuri Li,
- Yizhi Liu,
- Nilesh J. Samani,
- Yihai Cao
Affiliations
- Takahiro Seki
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Kayoko Hosaka
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Sharon Lim
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Carina Fischer
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Jennifer Honek
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Yunlong Yang
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Patrik Andersson
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Masaki Nakamura
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Erik Näslund
- Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute
- Seppo Ylä-Herttuala
- Department of Molecular Medicine, A.I. Virtanen Institute, Molecular Sciences University of Eastern Finland
- Meili Sun
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Hideki Iwamoto
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- Xuri Li
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University
- Yizhi Liu
- State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University
- Nilesh J. Samani
- Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital
- Yihai Cao
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
- DOI
- https://doi.org/10.1038/ncomms12152
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
Cold-induced activation of thermogenesis in white adipose tissue (WAT), or ‘beiging’, is associated with WAT angiogenesis. Here the authors show that PDGF-CC is secreted from endothelial cells in the context of WAT angiogenesis and its paracrine action on adipocytes contributes to cold-induced beiging.
