Nature Communications (Jul 2016)

Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells

  • Pingsu Mao,
  • Jingfan Liu,
  • Zepeng Zhang,
  • Hong Zhang,
  • Haiying Liu,
  • Song Gao,
  • Yikang S. Rong,
  • Yong Zhao

DOI
https://doi.org/10.1038/ncomms12154
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

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Telomeres protect the ends of chromosomes from the DNA damage recognition machinery, however how damage in telomeres is repaired is poorly understood. Here the authors use CRISPR-Cas9 to induce DNA breaks and identify proliferation dependent homologous recombination repair.