Bee venom phonophoresis on mild to moderate localized plaque psoriasis on a knee joint: a randomized controlled trial

Abstract

Introduction. In psoriasis, plaque psoriasis is the most common kind. Patients may experience mild to severe symptoms, and while the sickness is not lethal, it is difficult to cure. Aim. The purpose of this study is to evaluate the efficacy of bee venom phonophoresis in treating mild to moderate plaque psoriasis of the knee. Materials and methods. Group A received bee venom phonophoresis in conjunction with conservative care, group B received bee venom topical application in conjunction with conservative care, and group C served as a control in a double-blind randomized controlled experiment including 96 patients with plaque psoriasis. Over the course of three months, every patient underwent a thorough evaluation that included blood tests to measure systemic inflammation (Neutrophil to lymphocyte ratio, C-reactive protein, and erythrocyte sedimentation rate), as well as PASI (Psoriasis Area and Severity Index) and Isokinetic knee proprioceptive. Results and disscusion. No statistically significant difference was found between the three groups at baseline measurement; however, a treatment effect was observed after 12 weeks of treatment (p = 0.001 and f-value = 50.718). In addition, both groups (A and B) showed a statistically significant interaction between pre- and post-treatment treatment and time; however, this interaction was much more pronounced and noticeable in group A. Conclusion. Phonophoresis with bee venom improves proprioception in the knee joint and decreases N/L ratio, CRP, ESR, and PASI. Registration: Clinicaltrials.gov identifier No. NCT06106230; registered 20.10.2023.

Keywords

• bee venom
• plaque psoriasis
• systemic inflammation
• knee joint proprioception
• phonophoresis