Nature Communications (Jun 2021)
Cellular and physiological circadian mechanisms drive diurnal cell proliferation and expansion of white adipose tissue
- Aleix Ribas-Latre,
- Rafael Bravo Santos,
- Baharan Fekry,
- Yomna M. Tamim,
- Samay Shivshankar,
- Alaa M. T. Mohamed,
- Corrine Baumgartner,
- Christopher Kwok,
- Claudia Gebhardt,
- Angielyn Rivera,
- Zhanguo Gao,
- Kai Sun,
- John T. Heiker,
- Brad E. Snyder,
- Mikhail G. Kolonin,
- Kristin L. Eckel-Mahan
Affiliations
- Aleix Ribas-Latre
- Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center
- Rafael Bravo Santos
- Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center
- Baharan Fekry
- Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center
- Yomna M. Tamim
- Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center
- Samay Shivshankar
- Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center
- Alaa M. T. Mohamed
- Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center
- Corrine Baumgartner
- Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center
- Christopher Kwok
- Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center
- Claudia Gebhardt
- Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig
- Angielyn Rivera
- Memorial Hermann Texas Medical Center
- Zhanguo Gao
- Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center
- Kai Sun
- Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center
- John T. Heiker
- Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig
- Brad E. Snyder
- Memorial Hermann Texas Medical Center
- Mikhail G. Kolonin
- Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center
- Kristin L. Eckel-Mahan
- Institute of Molecular Medicine, McGovern Medical School at the University of Texas Health Science Center
- DOI
- https://doi.org/10.1038/s41467-021-23770-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 18
Abstract
During the expansion of adipose tissue adipocyte progenitor cells proliferate and undergo adipogenesis. Here, the authors show that adipocyte progenitor cell proliferation in visceral adipose tissue has a diurnal pattern, which is dependent on both energy intake and the circadian clock.
