Frontiers in Immunology (Dec 2017)
Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System
- Yosuke Kurashima,
- Yosuke Kurashima,
- Yosuke Kurashima,
- Yosuke Kurashima,
- Yosuke Kurashima,
- Yosuke Kurashima,
- Daiki Yamamoto,
- Sean Nelson,
- Satoshi Uematsu,
- Satoshi Uematsu,
- Satoshi Uematsu,
- Peter B. Ernst,
- Peter B. Ernst,
- Peter B. Ernst,
- Toshinori Nakayama,
- Toshinori Nakayama,
- Toshinori Nakayama,
- Hiroshi Kiyono,
- Hiroshi Kiyono,
- Hiroshi Kiyono,
- Hiroshi Kiyono
Affiliations
- Yosuke Kurashima
- Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
- Yosuke Kurashima
- Division of Clinical Vaccinology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
- Yosuke Kurashima
- Institute for Global Prominent Research, Chiba University, Chiba, Japan
- Yosuke Kurashima
- Department of Mucosal Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Yosuke Kurashima
- Department of Innovative Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
- Yosuke Kurashima
- Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), San Diego, CA, Unites States
- Daiki Yamamoto
- Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
- Sean Nelson
- Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
- Satoshi Uematsu
- Department of Mucosal Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Satoshi Uematsu
- Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), San Diego, CA, Unites States
- Satoshi Uematsu
- Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
- Peter B. Ernst
- Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), San Diego, CA, Unites States
- Peter B. Ernst
- Center for Veterinary Sciences and Comparative Medicine, University of California, San Diego, CA, Unites States
- Peter B. Ernst
- Division of Comparative Pathology and Medicine, Department of Pathology, University of California, San Diego, CA, Unites States
- Toshinori Nakayama
- Institute for Global Prominent Research, Chiba University, Chiba, Japan
- Toshinori Nakayama
- Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), San Diego, CA, Unites States
- Toshinori Nakayama
- 0Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
- Hiroshi Kiyono
- Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
- Hiroshi Kiyono
- Division of Clinical Vaccinology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
- Hiroshi Kiyono
- Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), San Diego, CA, Unites States
- Hiroshi Kiyono
- 0Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
- DOI
- https://doi.org/10.3389/fimmu.2017.01787
- Journal volume & issue
-
Vol. 8
Abstract
Stromal connective tissue contains mesenchymal cells, including fibroblasts and myofibroblasts, which line the tissue structure. However, it has been identified that the function of mesenchymal cells is not just structural—they also play critical roles in the creation and regulation of intestinal homeostasis. Thus, mucosal mesenchymal cells instruct intestinal immune cell education (or peripheral immune education) and epithelial cell differentiation thereby shaping the local environment of the mucosal immune system. Malfunction of the mesenchymal cell-mediated instruction system (e.g., fibrosis) leads to pathological conditions such as intestinal stricture.
Keywords
