Nature Communications (Apr 2019)

Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis

  • Bo Gong,
  • Zhihao Li,
  • Wanghua Xiao,
  • Guangyuan Li,
  • Shihui Ding,
  • Anming Meng,
  • Shunji Jia

DOI
https://doi.org/10.1038/s41467-019-09604-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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The growth factor VEGF is known to regulate vasculogenesis but the downstream pathways activated are unclear. Here, the authors report that Sec14l3, a member of the PITP (phosphatidyl inositol transfer proteins) family regulates the formation of zebrafish vasculature by promoting VEGFR2 endocytic trafficking.