PLoS ONE (Jan 2024)

Effects of moderate doses of ionizing radiation on experimental abdominal aortic aneurysm.

  • Goran Riazi,
  • Chloe Brizais,
  • Imene Garali,
  • Rida Al-Rifai,
  • Helene Quelquejay,
  • Virginie Monceau,
  • Guillaume Vares,
  • Lea Ould-Boukhitine,
  • Damien Aubeleau,
  • Florian Gilain,
  • Celine Gloaguen,
  • Morgane Dos Santos,
  • Hafid Ait-Oufella,
  • Teni Ebrahimian

DOI
https://doi.org/10.1371/journal.pone.0308273
Journal volume & issue
Vol. 19, no. 8
p. e0308273

Abstract

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BackgroundExposure to ionizing radiation has been linked to cardiovascular diseases. However, the impact of moderate doses of radiation on abdominal aortic aneurysm (AAA) remains unknown.MethodsAngiotensin II-infused Apoe-/- mice were irradiated (acute, 1 Gray) either 3 days before (Day-3) or 1 day after (Day+1) pomp implantation. Isolated primary aortic vascular smooth muscle cells (VSMCs) were irradiated (acute 1 Gray) for mechanistic studies and functional testing in vitro.ResultsDay-3 and Day+1 irradiation resulted in a significant reduction in aorta dilation (Control: 1.39+/-0.12; Day-3: 1.12+/-0.11; Day+1: 1.15+/-0.08 mm, PConclusionModerate doses of ionizing radiation mitigate AAA either through VSCM phenotype or inflammation modulation, depending on the time of irradiation.