Thoracic Air-Leakage Syndrome in Allogeneic Stem Cell Transplant Recipients as a Late Complication of Chronic Graft-versus-Host Disease: Case Reports
Jae Woo Park,
Song Soo Kim,
Deog-Yeon Jo,
Hwan-Jung Yun,
Hyo Jin Lee,
Jin Hwan Kim
Affiliations
Jae Woo Park
Department of Radiology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea
Song Soo Kim
Department of Radiology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea
Deog-Yeon Jo
Division of Hematology and Oncology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea
Hwan-Jung Yun
Division of Hematology and Oncology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea
Hyo Jin Lee
Division of Hematology and Oncology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea
Jin Hwan Kim
Department of Radiology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea
Air-leakage syndrome associated with graft-versus-host disease (GVHD) is a rare complication, but it is also reported as an independent predictor of a worse survival rate after stem cell transplantation. We report two cases of air-leakage syndrome associated with GVHD after allogeneic stem cell transplantation in acute leukemia patients who presented with spontaneous pneumomediastinum and subcutaneous emphysema, and finally death due to respiratory failure seven to eight months later.
