Nature Communications (Oct 2017)

Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer

  • Govindi J. Samaranayake,
  • Clara I. Troccoli,
  • Mai Huynh,
  • Rolando D. Z. Lyles,
  • Karen Kage,
  • Andrew Win,
  • Vishalakshi Lakshmanan,
  • Deukwoo Kwon,
  • Yuguang Ban,
  • Steven Xi Chen,
  • Enrique Rodriguez Zarco,
  • Merce Jorda,
  • Kerry L. Burnstein,
  • Priyamvada Rai

DOI
https://doi.org/10.1038/s41467-017-01269-x
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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Identifying actionable components in castration–resistant prostate cancer (CRPC) is critical for the development of effective treatments. Here, the authors show that the inhibition of the redox-protective protein TRX1 decreases the growth of CRPC cells through the regulation of ROS levels, p53 and androgen receptor expression.