Nature Communications (Jul 2021)
Genetic influences on hub connectivity of the human connectome
- Aurina Arnatkeviciute,
- Ben D. Fulcher,
- Stuart Oldham,
- Jeggan Tiego,
- Casey Paquola,
- Zachary Gerring,
- Kevin Aquino,
- Ziarih Hawi,
- Beth Johnson,
- Gareth Ball,
- Marieke Klein,
- Gustavo Deco,
- Barbara Franke,
- Mark A. Bellgrove,
- Alex Fornito
Affiliations
- Aurina Arnatkeviciute
- The Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging, Monash University
- Ben D. Fulcher
- The Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging, Monash University
- Stuart Oldham
- The Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging, Monash University
- Jeggan Tiego
- The Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging, Monash University
- Casey Paquola
- McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University
- Zachary Gerring
- Translational Neurogenomics Laboratory, QIMR Berghofer Medical Research Institute
- Kevin Aquino
- The Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging, Monash University
- Ziarih Hawi
- The Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging, Monash University
- Beth Johnson
- The Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging, Monash University
- Gareth Ball
- Developmental Imaging, Murdoch Children’s Research Institute
- Marieke Klein
- Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour
- Gustavo Deco
- The Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging, Monash University
- Barbara Franke
- Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour
- Mark A. Bellgrove
- The Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging, Monash University
- Alex Fornito
- The Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging, Monash University
- DOI
- https://doi.org/10.1038/s41467-021-24306-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
How genes sculpt the complex architecture of the human connectome remains unclear. Here, the authors show that genes preferentially influence the strength of connectivity between functionally valuable, metabolically costly connections between brain network hubs.
