Impact of Cataract Surgery on Low Luminance Visual Acuity Deficit Measurements

Mengxi Shen, MD; Yingying Shi, MD; Liang Wang, BS; Jonathan F. Russell, MD, PhD; Xiaoshuang Jiang, MD, PhD; Rita Laiginhas, MD, PhD; Prashanth Iyer, MD, MPH; Omer Trivizki, MD; Marie Thulliez, MD; Sonia H. Yoo, MD; Terri P. Rose, OD, FAAO; Ranya G. Habash, MD; Guillermo Amescua, MD; William J. Feuer, MS; Giovanni Gregori, PhD; Philip J. Rosenfeld, MD, PhD

Ophthalmology Science (Sep 2022)

Impact of Cataract Surgery on Low Luminance Visual Acuity Deficit Measurements

Mengxi Shen, MD,
Yingying Shi, MD,
Liang Wang, BS,
Jonathan F. Russell, MD, PhD,
Xiaoshuang Jiang, MD, PhD,
Rita Laiginhas, MD, PhD,
Prashanth Iyer, MD, MPH,
Omer Trivizki, MD,
Marie Thulliez, MD,
Sonia H. Yoo, MD,
Terri P. Rose, OD, FAAO,
Ranya G. Habash, MD,
Guillermo Amescua, MD,
William J. Feuer, MS,
Giovanni Gregori, PhD,
Philip J. Rosenfeld, MD, PhD

Affiliations

Mengxi Shen, MD: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
Yingying Shi, MD: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
Liang Wang, BS: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
Jonathan F. Russell, MD, PhD: Institute for Vision Research and Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, Iowa
Xiaoshuang Jiang, MD, PhD: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
Rita Laiginhas, MD, PhD: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
Prashanth Iyer, MD, MPH: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
Omer Trivizki, MD: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
Marie Thulliez, MD: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
Sonia H. Yoo, MD: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
Terri P. Rose, OD, FAAO: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
Ranya G. Habash, MD: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
Guillermo Amescua, MD: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
William J. Feuer, MS: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
Giovanni Gregori, PhD: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
Philip J. Rosenfeld, MD, PhD: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; Correspondence: Philip J. Rosenfeld, MD, PhD, Department of Ophthalmology, Bascom Palmer Eye Institute, 900 NW 17th Street, Miami, FL 33136.

Journal volume & issue: Vol. 2, no. 3
p. 100170

Abstract

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Purpose: The impact of cataract surgery on low luminance visual acuity deficit (LLVAD) measurements was investigated by measuring the LLVAD before and after cataract surgery. Design: Prospective, longitudinal study. Participants: Patients undergoing cataract surgery. Methods: Photopic luminance (PL)–best-corrected visual acuity (BCVA) and low luminance (LL)–BCVA were obtained using the ETDRS chart. Low luminance visual acuity deficit scores were calculated by subtracting the LL-BCVA letter score from the PL-BCVA letter score. To demonstrate the reproducibility of these visual acuity measurements, we used data from drusen-only eyes previously published in the Complement Inhibition with Eculizumab for the Treatment of Nonexudative Age-Related Macular Degeneration (COMPLETE) study. The PL-BCVA, LL-BCVA, and LLVAD measurements obtained at an interval of 3 months in this cohort were used for comparison. In the current study, the impact of cataract surgery on LLVAD measurements was analyzed by comparing the PL-BCVA, LL-BCVA, and LLVAD measurements before and after cataract surgery. Main Outcome Measures: The reproducibility of the visual acuity measurements and the changes in LLVAD measurement after cataract surgery. Results: In the COMPLETE study, no clinically significant differences were found in the PL-BCVA, LL-BCVA, or LLVAD measurements between baseline and the 3-month follow-up visits with a change of –1.1 letters, –1.3 letters, and 0.1 letters, respectively (P = 0.02, P = 0.11, and P = 0.88, respectively). In the current study, significant increases were found in the PL-BCVA and LL-BCVA measurements, with a change of 7.3 letters and 10.2 letters after cataract surgery (P < 0.001 for both), and a statistically significant decrease in LLVAD measurements was found, with a change of –3.0 letters after cataract surgery (P = 0.002). Conclusions: Because of the variable effect of cataracts on LL-BCVA measurements and the significant change in LLVAD measurements after cataract surgery, investigators should be aware that cataract surgery during a trial will have an unpredictable impact on LLVAD measurements, and pseudophakic and phakic patients should be analyzed separately.

Published in Ophthalmology Science

ISSN: 2666-9145 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Ophthalmology
Website: https://www.journals.elsevier.com/ophthalmology-science/

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