A Structural Mimic of Carbonic Anhydrase in Zeolitic Imidazolate Frameworks via Trans-functionalization for Enhancing Hydrolytic Activity
Fanchen Meng,
Cheng Xu,
Linghai Zhang,
Xiaohan Huang,
Xinglong Zhang,
Wenlei Zhang,
Yongqi Luo,
Weina Zhang,
Wei Huang,
Fengwei Huo,
Suoying Zhang
Affiliations
Fanchen Meng
Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM) & School of Flexible Electronics (Future Technologies),
Nanjing Tech University, Nanjing 211816, P.R. China.
Cheng Xu
Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM) & School of Flexible Electronics (Future Technologies),
Nanjing Tech University, Nanjing 211816, P.R. China.
Linghai Zhang
Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM) & School of Flexible Electronics (Future Technologies),
Nanjing Tech University, Nanjing 211816, P.R. China.
Xiaohan Huang
Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM) & School of Flexible Electronics (Future Technologies),
Nanjing Tech University, Nanjing 211816, P.R. China.
Xinglong Zhang
Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM) & School of Flexible Electronics (Future Technologies),
Nanjing Tech University, Nanjing 211816, P.R. China.
Wenlei Zhang
Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM) & School of Flexible Electronics (Future Technologies),
Nanjing Tech University, Nanjing 211816, P.R. China.
Yongqi Luo
Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM) & School of Flexible Electronics (Future Technologies),
Nanjing Tech University, Nanjing 211816, P.R. China.
Weina Zhang
Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM) & School of Flexible Electronics (Future Technologies),
Nanjing Tech University, Nanjing 211816, P.R. China.
Wei Huang
Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM) & School of Flexible Electronics (Future Technologies),
Nanjing Tech University, Nanjing 211816, P.R. China.
Fengwei Huo
Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM) & School of Flexible Electronics (Future Technologies),
Nanjing Tech University, Nanjing 211816, P.R. China.
Suoying Zhang
Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM) & School of Flexible Electronics (Future Technologies),
Nanjing Tech University, Nanjing 211816, P.R. China.
Metal-organic frameworks (MOFs) have been widely considered as ideal platforms for the preparation of biomimetic catalysts, but it remains challenging to fabricate MOF-based enzyme-like catalysts with optimal activity. Here, we leverage the inherent flexibility of MOFs and propose a novel trans-functionalization strategy to construct a carbonic anhydrase (CA) mimic by the structural transformation from ZIF-L to ZIF-8. Theoretical and experimental results reveal that during the structural transformation, the hydroxyl group will preferentially coordinate with the interlayer Zn clusters to form the CA-like active center Zn-N3-OH. Therefore, more accessible active centers are generated on the as-prepared ZIF-8-OH, resulting in substantially enhanced catalytic activity in the hydrolysis of para-nitrophenyl acetate.
