Nature Communications (Feb 2023)
Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice
- Shan Yao,
- Min-Dong Xu,
- Ying Wang,
- Shen-Ting Zhao,
- Jin Wang,
- Gui-Fu Chen,
- Wen-Bing Chen,
- Jian Liu,
- Guo-Bin Huang,
- Wen-Juan Sun,
- Yan-Yan Zhang,
- Huan-Li Hou,
- Lei Li,
- Xiang-Dong Sun
Affiliations
- Shan Yao
- Department of Neurology of the Second Affiliated Hospital, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, School of Basic Medical Sciences, Guangzhou Medical University
- Min-Dong Xu
- Department of Neurology of the Second Affiliated Hospital, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, School of Basic Medical Sciences, Guangzhou Medical University
- Ying Wang
- Department of Neurology of the Second Affiliated Hospital, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, School of Basic Medical Sciences, Guangzhou Medical University
- Shen-Ting Zhao
- Department of Physiology, School of Basic Medical Sciences, Guangzhou Medical University
- Jin Wang
- Department of Physiology, Guangxi University of Science and Technology
- Gui-Fu Chen
- Department of Neurology of the Second Affiliated Hospital, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, School of Basic Medical Sciences, Guangzhou Medical University
- Wen-Bing Chen
- Institute of Life Science, Nanchang University
- Jian Liu
- Department of Neurology of the Second Affiliated Hospital, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, School of Basic Medical Sciences, Guangzhou Medical University
- Guo-Bin Huang
- Department of Neurology of the Second Affiliated Hospital, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, School of Basic Medical Sciences, Guangzhou Medical University
- Wen-Juan Sun
- Department of Physiology, Guangxi University of Science and Technology
- Yan-Yan Zhang
- Department of Neurology of the Second Affiliated Hospital, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, School of Basic Medical Sciences, Guangzhou Medical University
- Huan-Li Hou
- Department of Neurology of the Second Affiliated Hospital, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, School of Basic Medical Sciences, Guangzhou Medical University
- Lei Li
- School of Life Science and Technology, ShanghaiTech University
- Xiang-Dong Sun
- Department of Neurology of the Second Affiliated Hospital, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, School of Basic Medical Sciences, Guangzhou Medical University
- DOI
- https://doi.org/10.1038/s41467-023-36209-5
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
The role of glycolysis in depression is unclear. Here the authors report a glycolytic deficit under social stress and demonstrate that astrocytic LDHA affects neuronal excitability and depressive-like behaviours via lactate homeostasis in mice.
