High force catch bond mechanism of bacterial adhesion in the human gut

Zhaowei Liu; Haipei Liu; Andrés M. Vera; Rafael C. Bernardi; Philip Tinnefeld; Michael A. Nash

doi:10.1038/s41467-020-18063-x

Nature Communications (Aug 2020)

High force catch bond mechanism of bacterial adhesion in the human gut

Zhaowei Liu,
Haipei Liu,
Andrés M. Vera,
Rafael C. Bernardi,
Philip Tinnefeld,
Michael A. Nash

Affiliations

Zhaowei Liu: Institute of Physical Chemistry, Department of Chemistry, University of Basel
Haipei Liu: Institute of Physical Chemistry, Department of Chemistry, University of Basel
Andrés M. Vera: Faculty of Chemistry and Center for NanoScience, Ludwig-Maximilians-Universität München
Rafael C. Bernardi: NIH Center for Macromolecular Modeling and Bioinformatics, Theoretical and Computational Biophysics Group, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign
Philip Tinnefeld: Faculty of Chemistry and Center for NanoScience, Ludwig-Maximilians-Universität München
Michael A. Nash: Institute of Physical Chemistry, Department of Chemistry, University of Basel

DOI: https://doi.org/10.1038/s41467-020-18063-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Understanding bacterial adhesion is important in a number of different areas of study. Here using a range of simulations and experimental methods, the authors, report on the molecular mechanism behind the binding of bacteria to cellulose fibers at high shear force in the human gut.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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