Journal of Clinical Medicine (Jun 2023)
<i>Helicobacter pylori</i> Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on <i>Helicobacter pylori</i> Management
- Natalia García-Morales,
- Ángeles Pérez-Aísa,
- Giulia Fiorini,
- Bojan Tepes,
- Manuel Castro-Fernández,
- Alfredo Lucendo,
- Irina Voynovan,
- Luis Bujanda,
- Ana Garre,
- Luis Rodrigo,
- Samuel Jesús Martínez Domínguez,
- Maja Denkovski,
- Jose M. Huguet Malavés,
- Laimas Jonaitis,
- Renate Bumane,
- Oleg Zaytsev,
- Pilar Mata Romero,
- Jesús Barrio,
- Luis Fernández-Salazar,
- Aiman Silkanovna Sarsenbaeva,
- Inmaculada Ortiz Polo,
- Sergey Alekseenko,
- Ilaria Maria Saracino,
- Dino Vaira,
- Alma Keco-Huerga,
- Dmitry Bordin,
- Antonio Gasbarrini,
- Frode Lerang,
- Theodore Rokkas,
- Juozas Kupčinskas,
- Marcis Leja,
- Gulustan Babayeva,
- Ricardo Marcos Pinto,
- Ante Tonkić,
- Sinead Smith,
- Perminder Phull,
- Gyorgy M. Buzas,
- Halis Simsek,
- Doron Boltin,
- Oleksiy Gridnyev,
- Marino Venerito,
- Vladimir Milivojevic,
- Núria Torà,
- Anna Cano-Català,
- Leticia Moreira,
- Olga P. Nyssen,
- Francis Mégraud,
- Colm O’Morain,
- Javier P. Gisbert,
- Ignasi Puig,
- on behalf of Hp-EuReg Investigators
Affiliations
- Natalia García-Morales
- Digestive Service, Complexo Hospitalario Universitario de Vigo, Sergas, South Galicia Health Research Institute, 36312 Vigo, Spain
- Ángeles Pérez-Aísa
- Unidad de Digestivo, Hospital Costa del Sol Marbella, Redes de Investigación Cooperativa Orientada a Resultados en Salud (RICORS), 29603 Marbella, Spain
- Giulia Fiorini
- Department of Surgical and Medical Sciences, IRCCS AOU S. Orsola, 39015 Bologna, Italy
- Bojan Tepes
- AM DC Rogaska, 3250 Rogaska Slatina, Slovenia
- Manuel Castro-Fernández
- Hospital Valme, 41014 Sevilla, Spain
- Alfredo Lucendo
- Hospital de Tomelloso, 13700 Ciudad Real, Spain
- Irina Voynovan
- A.S. Loginov, Clinical Scientific Centre, 111123 Moscow, Russia
- Luis Bujanda
- Department of Gastroenterology, Biodonostia Health Research Institute, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Universidad del País Vasco (UPV/EHU), 20014 San Sebastián, Spain
- Ana Garre
- Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain
- Luis Rodrigo
- Hospital Central de Asturias, 33011 Oviedo, Spain
- Samuel Jesús Martínez Domínguez
- Hospital Clínico Lozano Blesa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 50009 Zaragoza, Spain
- Maja Denkovski
- Diagnostic Center Bled, 4260 Bled, Slovenia
- Jose M. Huguet Malavés
- Hospital General Universitario de Valencia, 46014 Valencia, Spain
- Laimas Jonaitis
- Department of Gastroenterology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania
- Renate Bumane
- Digestive Diseases Centre GASTRO, LV-1006 Riga, Latvia
- Oleg Zaytsev
- First Clinical Medical Centre, 601900 Kovrov, Russia
- Pilar Mata Romero
- Hospital Universitario de Cáceres, 10004 Cáceres, Spain
- Jesús Barrio
- Hospital Rio Hortega, 47012 Valladolid, Spain
- Luis Fernández-Salazar
- Hospital Clínico de Valladolid, 47003 Valladolid, Spain
- Aiman Silkanovna Sarsenbaeva
- Gastroenterologist Department of Regional Clinical Hospital N3, 454080 Chelyabinsk, Russia
- Inmaculada Ortiz Polo
- Hospital la Fe, 46026 Valencia, Spain
- Sergey Alekseenko
- Far Eastern State Medical University, 680000 Khabarovsk, Russia
- Ilaria Maria Saracino
- Department of Surgical and Medical Sciences, IRCCS AOU S. Orsola, 39015 Bologna, Italy
- Dino Vaira
- Department of Surgical and Medical Sciences, IRCCS AOU S. Orsola, 39015 Bologna, Italy
- Alma Keco-Huerga
- Hospital Valme, 41014 Sevilla, Spain
- Dmitry Bordin
- Gastroenterology Unit, A.S. Loginov Moscow Clinical Scientific Center, 111123 Moscow, Russia
- Antonio Gasbarrini
- Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
- Frode Lerang
- Central Hospital of Ostfold, 1601 Fredrikstad, Norway
- Theodore Rokkas
- Henry Dunant Hospital, 115 26 Athens, Greece
- Juozas Kupčinskas
- Department of Gastroenterology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania
- Marcis Leja
- Digestive Diseases Centre GASTRO, LV-1006 Riga, Latvia
- Gulustan Babayeva
- Memorial Klinika, 1096 Baku, Azerbaijan
- Ricardo Marcos Pinto
- Centro Hospitalario do Porto, 4050-101 Porto, Portugal
- Ante Tonkić
- Department Gastroenterol & Hepatol, University Hospital Centre Split, 2100 Split, Croatia
- Sinead Smith
- Tallaght Hospital, DR24 NR0A Dublin, Ireland
- Perminder Phull
- Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK
- Gyorgy M. Buzas
- Gastroenterology, Ferencváros Health Centre, Mester utca 45, 1095 Budapest, Hungary
- Halis Simsek
- Internal Med Gastroenterol Department, Hacettepe University School of Medicine, 06230 Ankara, Turkey
- Doron Boltin
- Division of Gastroenterology, Rabin Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv 4941492, Israel
- Oleksiy Gridnyev
- L.T. Malaya Therapy National Institute of the National Academy of Medical Sciences, ID 70483 Kharkiv, Ukraine
- Marino Venerito
- Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, 44, 39120 Magdeburg, Germany
- Vladimir Milivojevic
- Clinical Center of Serbia, 11000 Belgrade, Serbia
- Núria Torà
- GOES Research Group, Unitat de Recerca i Innovació, Athaia Xarxa Assistencial Universitària de Manresa, 08243 Manresa, Spain
- Anna Cano-Català
- GOES Research Group, Unitat de Recerca i Innovació, Athaia Xarxa Assistencial Universitària de Manresa, 08243 Manresa, Spain
- Leticia Moreira
- Hospital Clínic de Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERed), 08036 Barcelona, Spain
- Olga P. Nyssen
- Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain
- Francis Mégraud
- INSERM U1312, Université de Bordeaux, 33000 Bordeaux, France
- Colm O’Morain
- Rabin Medical Center, Beilinson Campus, Petah Tikva 49100, Israel
- Javier P. Gisbert
- Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Universidad Autónoma de Madrid (UAM) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28006 Madrid, Spain
- Ignasi Puig
- Althaia Xarxa Assistencial Universitària de Manresa and Universitat de Vic-Universitat Central de Catalunya (UVicUCC), 08242 Manresa, Spain
- on behalf of Hp-EuReg Investigators
- DOI
- https://doi.org/10.3390/jcm12134363
- Journal volume & issue
-
Vol. 12,
no. 13
p. 4363
Abstract
Background and aims: Several methods are available to diagnose Helicobacter pylori infection. Our objective was to evaluate the tests used for both the initial diagnosis and the confirmation of eradication after treatment in Europe. Methods: The European Registry on the management of Helicobacter pylori infection is an international, multicentre, prospective, non-interventional registry aiming to evaluate the management of Helicobacter pylori-infected patients in Europe. Countries with at least 100 cases registered from June 2013 to April 2021, and with a validated diagnostic method were analysed. Data were quality reviewed. Results: A total of 34,920 adult patients from 20 countries were included (mean age 51 years; 61% women). To establish the initial diagnosis, invasive tests were performed in 19,801 (71%) patients, non-invasive in 11,369 (41%), and both in 3437 (12%). The most frequent were histology (n = 11,885; 43%), a rapid urease test (n = 10,636; 38%) and an urea breath test (n = 7577; 27%). According to the age, invasive tests were indicated in 11,179 (77%) ≥50 years, and in 8603 (65%) <50 years. Depending on the country, the use of invasive tests ranged from 29–99% in <50 years to 60–99% in ≥50. Most of the tests used to confirm eradication were non-invasive (n = 32,540; 93%), with the urea breath test being the most frequent (n = 32,540; 78%). In 2983 (9%) post-treatment tests, histology (n = 1887; 5%) or a rapid urease test (n = 1223; 4%) were performed. Conclusion: A great heterogeneity was observed for the initial diagnosis and confirmation of the eradication. The reasons for the apparent lack of adherence to the clinical guidelines should be further explored.
Keywords