Nature Communications (Sep 2019)
Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross
- Juliana M. Sá,
- Sarah R. Kaslow,
- Roberto R. Moraes Barros,
- Nicholas F. Brazeau,
- Christian M. Parobek,
- Dingyin Tao,
- Rebecca E. Salzman,
- Tyler J. Gibson,
- Soundarapandian Velmurugan,
- Michael A. Krause,
- Viviana Melendez-Muniz,
- Whitney A. Kite,
- Paul K. Han,
- Richard T. Eastman,
- Adam Kim,
- Evan G. Kessler,
- Yonas Abebe,
- Eric R. James,
- Sumana Chakravarty,
- Sachy Orr-Gonzalez,
- Lynn E. Lambert,
- Theresa Engels,
- Marvin L. Thomas,
- Pius S. Fasinu,
- David Serre,
- Robert W. Gwadz,
- Larry Walker,
- Derrick K. DeConti,
- Jianbing Mu,
- Jeffrey A. Bailey,
- B. Kim Lee Sim,
- Stephen L. Hoffman,
- Michael P. Fay,
- Rhoel R. Dinglasan,
- Jonathan J. Juliano,
- Thomas E. Wellems
Affiliations
- Juliana M. Sá
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Sarah R. Kaslow
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Roberto R. Moraes Barros
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Nicholas F. Brazeau
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Christian M. Parobek
- Curriculum in Genetics and Molecular Biology, School of Medicine, University of North Carolina at Chapel Hill
- Dingyin Tao
- W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health
- Rebecca E. Salzman
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Tyler J. Gibson
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Soundarapandian Velmurugan
- Sanaria Inc.
- Michael A. Krause
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Viviana Melendez-Muniz
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Whitney A. Kite
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Paul K. Han
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Richard T. Eastman
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Adam Kim
- Institute for Genome Sciences, University of Maryland School of Medicine
- Evan G. Kessler
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Yonas Abebe
- Sanaria Inc.
- Eric R. James
- Sanaria Inc.
- Sumana Chakravarty
- Sanaria Inc.
- Sachy Orr-Gonzalez
- Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Lynn E. Lambert
- Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Theresa Engels
- Division of Veterinary Resources, Office of Research Services, National Institutes of Health
- Marvin L. Thomas
- Division of Veterinary Resources, Office of Research Services, National Institutes of Health
- Pius S. Fasinu
- Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Campbell University
- David Serre
- Institute for Genome Sciences, University of Maryland School of Medicine
- Robert W. Gwadz
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Larry Walker
- Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Campbell University
- Derrick K. DeConti
- Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School
- Jianbing Mu
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Jeffrey A. Bailey
- Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Campbell University
- B. Kim Lee Sim
- Sanaria Inc.
- Stephen L. Hoffman
- Sanaria Inc.
- Michael P. Fay
- Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Rhoel R. Dinglasan
- W Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health
- Jonathan J. Juliano
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Thomas E. Wellems
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-019-12256-9
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
Here, a cross of Plasmodium vivax malaria parasites links a chloroquine resistance (CQR) phenotype to a 76 kb region of chromosome 1 and greater expression of pvcrt, an ortholog of the Plasmodium falciparum CQR transporter gene.
