Nature Communications (Jan 2020)
Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
- Ellis Chika Onwordi,
- Els F. Halff,
- Thomas Whitehurst,
- Ayla Mansur,
- Marie-Caroline Cotel,
- Lisa Wells,
- Hannah Creeney,
- David Bonsall,
- Maria Rogdaki,
- Ekaterina Shatalina,
- Tiago Reis Marques,
- Eugenii A. Rabiner,
- Roger N. Gunn,
- Sridhar Natesan,
- Anthony C. Vernon,
- Oliver D. Howes
Affiliations
- Ellis Chika Onwordi
- Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital
- Els F. Halff
- Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
- Thomas Whitehurst
- Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital
- Ayla Mansur
- Division of Brain Sciences, Imperial College London, The Commonwealth Building, Hammersmith Hospital
- Marie-Caroline Cotel
- Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London
- Lisa Wells
- Invicro Imaging Services, Burlington Danes Building
- Hannah Creeney
- Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London
- David Bonsall
- Invicro Imaging Services, Burlington Danes Building
- Maria Rogdaki
- Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital
- Ekaterina Shatalina
- Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital
- Tiago Reis Marques
- Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital
- Eugenii A. Rabiner
- Invicro Imaging Services, Burlington Danes Building
- Roger N. Gunn
- Division of Brain Sciences, Imperial College London, The Commonwealth Building, Hammersmith Hospital
- Sridhar Natesan
- Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital
- Anthony C. Vernon
- Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King’s College London
- Oliver D. Howes
- Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital
- DOI
- https://doi.org/10.1038/s41467-019-14122-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis. Here, using [11C]UCB-J PET, the authors show for the first time in vivo that levels of the synaptic marker protein SV2A are reduced in schizophrenia and unaffected by antipsychotic treatment in a rat model.
