Nature Communications (Sep 2021)
Parity associates with chromosomal damage in uterine leiomyomas
- Heli Kuisma,
- Simona Bramante,
- Kristiina Rajamäki,
- Lauri J. Sipilä,
- Eevi Kaasinen,
- Jaana Kaukomaa,
- Kimmo Palin,
- Netta Mäkinen,
- Jari Sjöberg,
- Nanna Sarvilinna,
- Jussi Taipale,
- Liisa Kauppi,
- Manuela Tumiati,
- Antti Hassinen,
- Janne Pitkäniemi,
- Jyrki Jalkanen,
- Sanna Heikkinen,
- Annukka Pasanen,
- Oskari Heikinheimo,
- Ralf Bützow,
- Niko Välimäki,
- Lauri A. Aaltonen
Affiliations
- Heli Kuisma
- Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program University of Helsinki
- Simona Bramante
- Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program University of Helsinki
- Kristiina Rajamäki
- Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program University of Helsinki
- Lauri J. Sipilä
- Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program University of Helsinki
- Eevi Kaasinen
- Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program University of Helsinki
- Jaana Kaukomaa
- Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program University of Helsinki
- Kimmo Palin
- Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program University of Helsinki
- Netta Mäkinen
- Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program University of Helsinki
- Jari Sjöberg
- Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital
- Nanna Sarvilinna
- Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital
- Jussi Taipale
- Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program University of Helsinki
- Liisa Kauppi
- Systems Oncology Research Program, University of Helsinki
- Manuela Tumiati
- Systems Oncology Research Program, University of Helsinki
- Antti Hassinen
- FIMM-HCA, Institute for Molecular Medicine Finland (FIMM)
- Janne Pitkäniemi
- Institute for Statistical and Epidemiological Cancer Research, Finnish Cancer Registry
- Jyrki Jalkanen
- Department of Obstetrics and Gynecology, Central Finland Central Hospital
- Sanna Heikkinen
- Institute for Statistical and Epidemiological Cancer Research, Finnish Cancer Registry
- Annukka Pasanen
- Department of Pathology, University of Helsinki and Helsinki University Hospital
- Oskari Heikinheimo
- Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital
- Ralf Bützow
- Department of Pathology, University of Helsinki and Helsinki University Hospital
- Niko Välimäki
- Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program University of Helsinki
- Lauri A. Aaltonen
- Department of Medical and Clinical Genetics and Applied Tumor Genomics Research Program University of Helsinki
- DOI
- https://doi.org/10.1038/s41467-021-25806-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Many factors have been associated with chromosomal damage, including mechanical forces in a constrained cellular environment. Here the authors reveal an association between parity and chromosomal damage by analysing karyotypes of 1946 uterine leiomyomas.
