A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis

Yutaka Takahara; Kouichi Yamamura; Saki Matsuura; Takashi Sakuma; Kazuaki Nishiki; Keisuke Nakase; Masafumi Nojiri; Ryo Kato; Shohei Shinomiya; Rieko Oikawa; Yuki Fujimoto; Taku Oikawa; Kazuhiro Osanai; Yoshimichi Ueda; Shiro Mizuno

Respiratory Medicine Case Reports (Jan 2020)

A case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis

Yutaka Takahara,
Kouichi Yamamura,
Saki Matsuura,
Takashi Sakuma,
Kazuaki Nishiki,
Keisuke Nakase,
Masafumi Nojiri,
Ryo Kato,
Shohei Shinomiya,
Rieko Oikawa,
Yuki Fujimoto,
Taku Oikawa,
Kazuhiro Osanai,
Yoshimichi Ueda,
Shiro Mizuno

Affiliations

Yutaka Takahara: Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan; Corresponding author.
Kouichi Yamamura: Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan
Saki Matsuura: Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan
Takashi Sakuma: Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan
Kazuaki Nishiki: Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan
Keisuke Nakase: Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan
Masafumi Nojiri: Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan
Ryo Kato: Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan
Shohei Shinomiya: Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan
Rieko Oikawa: Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan
Yuki Fujimoto: Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan
Taku Oikawa: Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan
Kazuhiro Osanai: Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan
Yoshimichi Ueda: Department of Pathology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan
Shiro Mizuno: Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa, 920-0293, Japan

Journal volume & issue: Vol. 30
p. 101124

Abstract

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A 53-year-old woman was referred to our hospital for detailed examination of abnormal chest shadows recognized on CT imaging. Transbronchial lung biopsy of a right S6 nodular shadow led to a diagnosis of lung adenocarcinoma. FDG-PET-CT showed FDG accumulation in the Th11 and L2 vertebral bodies and osteoblastic bone lesions. Since osteoblastic bone metastasis in lung cancer is extremely rare, CT-guided bone biopsy was performed. The tumor was diagnosed as ROS1-rearranged lung adenocarcinoma, for which crizotinib was administered, which led to improvement of both the primary and metastatic lesions. We report here a rare case of ROS1-rearranged lung adenocarcinoma with osteoblastic bone metastasis of lung cancer.

Published in Respiratory Medicine Case Reports

ISSN: 2213-0071 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the respiratory system
Website: http://www.journals.elsevier.com/respiratory-medicine-case-reports/

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