Identification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting

Huan Liu; Elizabeth J. Leslie; Jenna C. Carlson; Terri H. Beaty; Mary L. Marazita; Andrew C. Lidral; Robert A. Cornell

doi:10.1038/ncomms14759

Nature Communications (Mar 2017)

Identification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting

Huan Liu,
Elizabeth J. Leslie,
Jenna C. Carlson,
Terri H. Beaty,
Mary L. Marazita,
Andrew C. Lidral,
Robert A. Cornell

Affiliations

Huan Liu: Department of Anatomy and Cell Biology, College of Medicine, University of Iowa
Elizabeth J. Leslie: Department of Oral Biology, Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh
Jenna C. Carlson: Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh
Terri H. Beaty: Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University
Mary L. Marazita: Department of Oral Biology, Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh
Andrew C. Lidral: Department of Orthodontics, College of Dentistry, University of Iowa
Robert A. Cornell: Department of Anatomy and Cell Biology, College of Medicine, University of Iowa

DOI: https://doi.org/10.1038/ncomms14759
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

Many genetic variants have been associated with complex congenital disorders, but their function is not always clear. Here, the authors develop a pipeline to functionally characterize such variants, and show potential roles for three SNPs in non-syndromic cleft lip and palate.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal