Frequency of detection of some markers of endothelial dysfunction in patients with inflammatory bowel diseases

Abstract

Aim. The purpose of our study was to determine the frequency of detection of some markers of endothelial dysfunction in patients with inflammatory bowel disease (IBD). Materials and methods. The study was conducted on the basis of the Therapy Department of of A. Aliyev Azerbaijan State Advanced Training Institute for Doctors, the Department of Inflammatory Bowel Diseases "MedEra Hospital" and "Memorial Klinika" between March 2015 and September 2017. In patients with ulcerative colitis and Crohn's disease, homocysteine (Axis-Shield, IFA method) and hs-CRP (Biomerica, IFA method) in the blood, albumin (MicralTest, Roche Diagnostics) in urine were determined. The study included 87 patients with inflammatory bowel diseases (the diagnosis was confirmed on the basis of ECCO recommendations) in whom there was no history of nephro-, cerebro- and cardiovascular pathology in the anamnesis. Results and discussion. Of the 48 patients with Crohn's disease, 45 homocysteine levels were elevated and comprised 12.9–48.7 μmol/L in the 15–60 year old; and in the group of patients older than 60 years fluctuated within 16.5–34.6 μmol/L. Out of 48 patients with Crohn's disease, 47 showed both albuminuria (micro- and macroalbuminuria) and was 22.8–98.5 mg/L. Of the 48 patients with Crohn's disease, 31 had an increase in hs-CRP between 4.3–47.1 mg/L; of them in 14 patients less than 10 mg/L, in 8 patients from 10.1–20.0 mg/L, and in 9 patients it ranged more than 20.0 mg/L. Of the 39 patients with ulcerative colitis, the level of homocysteine in 33 was elevated and amounted to 13.4–48.7 μmol/L in the 17–40 year old group; in the 41–59 year old group, 14.9–31.3 μmol/L; and in the group of patients older than 60 years fluctuated within the range of 16.9–41.7 μmol/L. Out of 39 patients with ulcerative colitis, 24 had albuminuria (both micro- and macroalbuminuria) and was 21.9–146.5 mg/L. Of 39 patients with ulcerative colitis in 36, an increase in hs-CRP was observed in the range 3.5–118.7 mg/L; of them in 17 patients less than 10 mg/L, in 6 patients from 10.1–20.0 mg/L, in 13 patients it ranged more than 20.0 mg/L. Conclusion. The frequency of detection of some markers of endothelial dysfunction in Crohn's disease was on the average 85.3%: for homocysteine 93.7%; for hs-CRP 64.5%; for albuminuria 97.9%, and for ulcerative colitis averaged 79.4%: for homocysteine, 84.6%; for hs-CRP 92.3%; for albuminuria 61.5%. Because of the high incidence of these markers, patients with inflammatory bowel diseases need a multi-disciplinary approach.

Keywords

• endothelial dysfunction
• homocysteine
• albuminuria
• high-sensitivity C-reactive protein
• inflammatory bowel disease