PLoS ONE (Jan 2015)

Cancer-Related Causes of Death among HIV-Infected Patients in France in 2010: Evolution since 2000.

  • Marie-Anne Vandenhende,
  • Caroline Roussillon,
  • Sandrine Henard,
  • Philippe Morlat,
  • Eric Oksenhendler,
  • Hugues Aumaitre,
  • Aurore Georget,
  • Thierry May,
  • Eric Rosenthal,
  • Dominique Salmon,
  • Patrice Cacoub,
  • Dominique Costagliola,
  • Geneviève Chêne,
  • Fabrice Bonnet,
  • ANRS EN20 Mortalité 2010 study group

DOI
https://doi.org/10.1371/journal.pone.0129550
Journal volume & issue
Vol. 10, no. 6
p. e0129550

Abstract

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ObjectivesThe current study aimed at describing the distribution and characteristics of malignancy related deaths in human immunodeficiency virus (HIV) infected patients in 2010 and at comparing them to those obtained in 2000 and 2005.MethodsData were obtained from three national surveys conducted in France in 2010, 2005 and 2000. The underlying cause of death was documented using a standardized questionnaire fulfilled in French hospital wards involved in the management of HIV infection.ResultsAmong the 728 deaths reported in 2010, 262 were cancer-related (36%). After a significant increase from 28% in 2000 to 33% in 2005 and 36% in 2010, cancers represent the leading cause of mortality in HIV infected patients. The proportion of deaths attributed to non-AIDS/non-hepatitis-related cancers significantly increased from 2000 to 2010 (11% of the deaths in 2000, 17% in 2005 and 22% in 2010, pConclusionsCancer prevention (especially smoking cessation), screening strategies and therapeutic management need to be optimized in HIV-infected patients in order to reduce mortality, particularly in the field of respiratory cancers.